Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.
Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.
复制标题
聚乙二醇修饰的单壁碳纳米管，用于关节内递送至软骨细胞。
DOI：
10.1021/nn504537b
复制
发表时间：
2014-12-23
期刊：
影响因子：
17.1
通讯作者：
Bottini, Massimo
中科院分区：
文献类型：
--
作者：
Sacchetti, Cristiano;Liu-Bryan, Ru;Magrini, Andrea;Rosato, Nicola;Bottini, Nunzio;Bottini, Massimo
关键词：
骨关节炎（OA）是一种常见的关节退行性疾病，目前尚无改善疾病的药物治疗。全身给药后，药物向软骨驻留的软骨细胞中的低效递送一直是抗OA药物开发的限制。直接关节内注射能够在软骨细胞附近递送高浓度的药剂;然而，这种方法的功效受到注射到滑膜腔中后小分子和生物大分子的快速清除的限制。药理学试剂与能够增强其停留时间和软骨渗透的药物递送系统的偶联可以增强关节内注射的抗OA药物的有效性。本文中，我们描述了一种基于用聚乙二醇（PEG）链修饰的单壁碳纳米管（SWCNT）（PEG-SWCNT）的有效关节内递送纳米系统。我们表明，PEG-SWCNTs能够在关节腔中持续很长一段时间，进入软骨基质，并将基因抑制剂递送到健康和OA小鼠的软骨细胞中。PEG-SWCNT纳米颗粒没有引起全身或局部副作用。我们的数据表明，PEG-SWCNTs代表了一种生物相容性和有效的纳米载体，用于关节内向软骨细胞递送药剂。
Osteoarthritis (OA) is a common and debilitating degenerative disease of articular joints for which no disease-modifying medical therapy is currently available. Inefficient delivery of pharmacologic agents into cartilage-resident chondrocytes after systemic administration has been a limitation to the development of anti-OA medications. Direct intra-articular injection enables delivery of high concentrations of agents in close proximity to chondrocytes; however, the efficacy of this approach is limited by the fast clearance of small molecules and biomacromolecules after injection into the synovial cavity. Coupling of pharmacologic agents with drug delivery systems able to enhance their residence time and cartilage penetration can enhance the effectiveness of intra-articularly injected anti-OA medications. Herein we describe an efficient intra-articular delivery nanosystem based on single-walled carbon nanotubes (SWCNTs) modified with polyethylene glycol (PEG) chains (PEG-SWCNTs). We show that PEG-SWCNTs are capable to persist in the joint cavity for a prolonged time, enter the cartilage matrix, and deliver gene inhibitors into chondrocytes of both healthy and OA mice. PEG-SWCNT nanoparticles did not elicit systemic or local side effects. Our data suggest that PEG-SWCNTs represent a biocompatible and effective nanocarrier for intra-articular delivery of agents to chondrocytes.
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DOI：
10.1016/j.clim.2012.12.011
发表时间：
2013-03
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Haseeb A;Haqqi TM
通讯作者：
Haqqi TM
影响因子：
10.8
作者：
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影响因子：
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作者：
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作者：
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通讯作者：
Bottini, Massimo
影响因子：
7
作者：
Glasson, S. S.;Blanchet, T. J.;Morris, E. A.
通讯作者：
Morris, E. A.