Epigenetics in β-cell adaptation and type 2 diabetes.

Epigenetics in β-cell adaptation and type 2 diabetes.
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DOI:
10.1016/j.coph.2020.10.008
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发表时间:
2020-12
影响因子:
4
通讯作者:
Kulkarni RN
Kulkarni RN
中科院分区:
医学3区
文献类型:
--
作者:
Kim H;Kulkarni RN

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健康的胰腺β细胞很好地适应全身性胰岛素抵抗以维持正常的血糖水平,如果不能适应这一过程,人类就会患上2型糖尿病。全基因组关联研究揭示了与2型糖尿病相关的遗传变异。但是,这仍然不足以解释这种疾病的高患病率。表观遗传学是研究不涉及DNA序列改变的基因表达变化,如DNA甲基化,组蛋白修饰和非编码RNA。近几十年来,大量研究表明表观遗传学在β细胞生物学中的作用。本文综述了β细胞适应和2型糖尿病的表观遗传学机制,包括染色质三维结构和RNA修饰。
Healthy pancreatic β-cells well adapt to systemic insulin resistance to maintain normal blood glucose levels, and failure to this process develops type 2 diabetes in humans. Genome-wide association studies uncovered genetic variants that are associated with type 2 diabetes. However, it is still insufficient to explain the high prevalence of this disease. Epigenetics is the study of gene expression changes that do not involve DNA sequence alterations such as DNA methylation, histone modification, and non-coding RNAs. In recent decades, a large number of studies demonstrated the roles of epigenetics in β-cell biology. In this review, we summarize the epigenetic mechanisms in β-cell adaptation and type 2 diabetes, which include three-dimensional chromatin structure and RNA modification.
DOI: 10.1038/s42255-019-0089-9
发表时间: 2019-08-01
期刊: NATURE METABOLISM
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