Altered amino acid profile in patients with SARS-CoV-2 infection.
Altered amino acid profile in patients with SARS-CoV-2 infection.
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DOI：
10.1073/pnas.2101708118
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发表时间：
2021-06-22
影响因子：
11.1
通讯作者：
Morris CR
中科院分区：
文献类型：
--
作者：
Rees CA;Rostad CA;Mantus G;Anderson EJ;Chahroudi A;Jaggi P;Wrammert J;Ochoa JB;Ochoa A;Basu RK;Heilman S;Harris F;Lapp SA;Hussaini L;Vos MB;Brown LA;Morris CR
血浆精氨酸生物利用度低与内皮功能障碍和免疫失调有关。精氨酸在COVID-19中的作用尚不清楚，但如果含量低，可能会导致细胞损伤。我们的目的是确定成人和儿童COVID-19患者与健康对照者的精氨酸生物利用度。我们假设精氨酸在COVID-19和儿童多系统炎症综合征（MIS-C）患者中的生物利用度较低。我们对三个患者队列进行了前瞻性观察研究；在无症状健康对照、COVID-19住院成人以及入院筛查中发现的COVID-19、MIS-C或无症状严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）感染的住院儿童/青少年中测定精氨酸的生物利用度。使用学生t检验将患者血浆氨基酸平均值与对照组进行比较。在所有三组中评估精氨酸与鸟氨酸的比值（精氨酸酶活性的生物标志物）和总体精氨酸生物利用比（GABR，精氨酸/[鸟氨酸+瓜氨酸]）。共纳入80例患者（28例对照，32例成人COVID-19患者和20例儿童COVID-19/MIS-C患者）。与对照组相比，成人和儿童COVID-19/MIS-C患者的平均血浆精氨酸和精氨酸生物利用度比较低。精氨酸在COVID-19患儿和misc患儿中的生物利用度没有差异。与健康成人对照相比，我们队列中患有COVID-19和misc的成人和儿童的精氨酸生物利用度较低。这可能导致COVID-19的免疫失调和内皮功能障碍。在COVID-19或misc患者中，精氨酸与鸟氨酸的比例较低表明精氨酸酶活性升高。精氨酸失调在COVID-19中的作用值得进一步研究。
Low plasma arginine bioavailability has been implicated in endothelial dysfunction and immune dysregulation. The role of arginine in COVID-19 is unknown, but could contribute to cellular damage if low. Our objective was to determine arginine bioavailability in adults and children with COVID-19 vs. healthy controls. We hypothesized that arginine bioavailability would be low in patients with COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We conducted a prospective observational study of three patient cohorts; arginine bioavailability was determined in asymptomatic healthy controls, adults hospitalized with COVID-19, and hospitalized children/adolescents <21 y old with COVID-19, MIS-C, or asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection identified on admission screen. Mean patient plasma amino acids were compared to controls using the Student’s t test. Arginine-to-ornithine ratio, a biomarker of arginase activity, and global arginine bioavailability ratio (GABR, arginine/[ornithine+citrulline]) were assessed in all three groups. A total of 80 patients were included (28 controls, 32 adults with COVID-19, and 20 pediatric patients with COVID-19/MIS-C). Mean plasma arginine and arginine bioavailability ratios were lower among adult and pediatric patients with COVID-19/MIS-C compared to controls. There was no difference between arginine bioavailability in children with COVID-19 vs. MIS-C. Adults and children with COVID-19 and MIS-C in our cohort had low arginine bioavailability compared to healthy adult controls. This may contribute to immune dysregulation and endothelial dysfunction in COVID-19. Low arginine-to-ornithine ratio in patients with COVID-19 or MIS-C suggests an elevation of arginase activity. Further study is merited to explore the role of arginine dysregulation in COVID-19.
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影响因子：
9.1
作者：
Reizine F;Lesouhaitier M;Gregoire M;Pinceaux K;Gacouin A;Maamar A;Painvin B;Camus C;Le Tulzo Y;Tattevin P;Revest M;Le Bot A;Ballerie A;Cador-Rousseau B;Lederlin M;Lebouvier T;Launey Y;Latour M;Verdy C;Rossille D;Le Gallou S;Dulong J;Moreau C;Bendavid C;Roussel M;Cogne M;Tarte K;Tadié JM
通讯作者：
Tadié JM
影响因子：
20.3
作者：
Morris, Claudia R.;Suh, Jung H.;Klings, Elizabeth S.
通讯作者：
Klings, Elizabeth S.
影响因子：
2.6
作者：
Grunwell JR;Gillespie SE;Ward JM;Fitzpatrick AM;Brown LA;Gauthier TW;Hebbar KB
通讯作者：
Hebbar KB
DOI：
10.1016/j.ejpsy.2020.10.004
发表时间：
2021-01
期刊：
The European journal of psychiatry
影响因子：
--
作者：
Attademo L;Bernardini F
通讯作者：
Bernardini F
影响因子：
7.5
作者：
Diorio C;McNerney KO;Lambert M;Paessler M;Anderson EM;Henrickson SE;Chase J;Liebling EJ;Burudpakdee C;Lee JH;Balamuth FB;Blatz AM;Chiotos K;Fitzgerald JC;Giglia TM;Gollomp K;Odom John AR;Jasen C;Leng T;Petrosa W;Vella LA;Witmer C;Sullivan KE;Laskin BL;Hensley SE;Bassiri H;Behrens EM;Teachey DT
通讯作者：
Teachey DT