Neurophysiological Basis of Deep Brain Stimulation and Botulinum Neurotoxin Injection for Treating Oromandibular Dystonia.
Neurophysiological Basis of Deep Brain Stimulation and Botulinum Neurotoxin Injection for Treating Oromandibular Dystonia.
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DOI：
10.3390/toxins14110751
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发表时间：
2022-11-02
期刊：
影响因子：
4.2
通讯作者：
Yoshida K
中科院分区：
文献类型：
--
作者：
Maezawa H;Hirata M;Yoshida K
口颌肌张力障碍（OMD）会引起严重的运动障碍，例如咀嚼障碍、吞咽困难和构音障碍，导致生活质量严重下降。脑电图 (EEG) 和脑磁图 (MEG) 等非侵入性脑成像技术是能够以高时间分辨率阐明人类皮层活动的强大方法。先前的脑电图和脑磁图研究表明，口颌系统的运动是由双侧中央皮层调节的。最近，除了将肉毒神经毒素（BoNT）注射到受影响的肌肉的标准疗法之外，双侧深部脑刺激（DBS）已被应用于OMD的治疗。然而，一些患者的 OMD 症状在 DBS 后没有得到充分改善，需要额外的 BoNT 治疗。在这篇综述中，我们使用脑电图和脑磁图概述了双侧皮层这些区域独特的中央时空处理机制，因为它们与口颌系统的感觉运动功能相关。增加对口颌系统神经生理学基础的了解将提高我们对 OMD 和其他运动障碍的理解，并有助于开发潜在的新方法，例如 BoNT 注射和 DBS 的联合治疗或非侵入性皮质电流刺激疗法。
Oromandibular dystonia (OMD) induces severe motor impairments, such as masticatory disturbances, dysphagia, and dysarthria, resulting in a serious decline in quality of life. Non-invasive brain-imaging techniques such as electroencephalography (EEG) and magnetoencephalography (MEG) are powerful approaches that can elucidate human cortical activity with high temporal resolution. Previous studies with EEG and MEG have revealed that movements in the stomatognathic system are regulated by the bilateral central cortex. Recently, in addition to the standard therapy of botulinum neurotoxin (BoNT) injection into the affected muscles, bilateral deep brain stimulation (DBS) has been applied for the treatment of OMD. However, some patients’ OMD symptoms do not improve sufficiently after DBS, and they require additional BoNT therapy. In this review, we provide an overview of the unique central spatiotemporal processing mechanisms in these regions in the bilateral cortex using EEG and MEG, as they relate to the sensorimotor functions of the stomatognathic system. Increased knowledge regarding the neurophysiological underpinnings of the stomatognathic system will improve our understanding of OMD and other movement disorders, as well as aid the development of potential novel approaches such as combination treatment with BoNT injection and DBS or non-invasive cortical current stimulation therapies.
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影响因子：
8.6
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