Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.
Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.
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DOI:
10.1007/s00018-011-0656-z
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发表时间:
2011-05
影响因子:
8
通讯作者:
Yewdell, Jonathan W.
中科院分区:
文献类型:
--
作者:
Dolan, Brian P.;Bennink, Jack R.;Yewdell, Jonathan W.
It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.
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影响因子:
7.8
作者:
Dostie, J;Lejbkowicz, F;Sonenberg, N
通讯作者:
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DOI:
10.1073/pnas.0400933101
发表时间:
2004-03-23
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