Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.

Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands.
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DOI:
10.1007/s00018-011-0656-z
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发表时间:
2011-05
影响因子:
8
通讯作者:
Yewdell, Jonathan W.
Yewdell, Jonathan W.
中科院分区:
生物学1区
文献类型:
--
作者:
Dolan, Brian P.;Bennink, Jack R.;Yewdell, Jonathan W.

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自我们提出缺陷核糖体产物(DRiP)假说来解释病毒肽通过MHC I类分子在感染细胞表面的快速呈递以来,已经过去了15年。在这里,我们回顾的证据DRiPs抗原加工的贡献,指出DRiPs的物理性质的不确定性,并强调最近的研究结果表明,肽的产生是一个专门的过程,涉及区室化翻译。
It has been 15 years since we proposed the defective ribosomal product (DRiP) hypothesis to explain the rapid presentation of viral peptides by MHC class I molecules on the surface of infected cells. Here, we review the evidence for the contribution of DRiPs to antigen processing, pointing to the uncertainties regarding the physical nature of DRiPs, and emphasizing recent findings suggesting that peptide generation is a specialized process involving compartmentalized translation.
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