Cardiovascular regulation profile predicts developmental trajectory of BMI and pediatric obesity.
Cardiovascular regulation profile predicts developmental trajectory of BMI and pediatric obesity.
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DOI：
10.1038/oby.2011.98
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发表时间：
2011-09
期刊：
影响因子：
6.9
通讯作者：
O'Brien, Marion
中科院分区：
文献类型：
--
作者：
Graziano, Paulo A.;Calkins, Susan D.;Keane, Susan P.;O'Brien, Marion
本研究探讨了心血管调节在预测儿童肥胖中的作用。这项研究的参与者包括从一项正在进行的大型纵向研究中获得的 268 名儿童（141 名女孩）。为了评估心脏迷走神经调节，我们在儿童 5.5 岁时对呼吸性窦性心律失常 (RSA) 和 RSA 变化（迷走神经退缩）进行了三项认知挑战性任务的静息测量。还检查了心率 (HP) 和 HP 变化（心率 (HR) 加速）。收集儿童 5.5、7.5 和 10.5 岁时的身高和体重测量值。结果表明，5.5 岁时的生理调节可以预测 10.5 岁时 BMI 发育的正常变化和儿童肥胖。具体而言，与具有高水平 RSA 抑制和 HP 变化为特征的心血管调节特征的儿童相比，具有以较低水平 RSA 抑制和 HP 变化为特征的心血管调节特征的儿童的 BMI 增长水平显着更高，并且在 10.5 岁时更有可能被归类为超重/超重风险。然而，发现与种族地位之间存在显着的相互作用，表明心血管调节状况与体重指数增长和儿童肥胖之间的关联仅对非裔美国儿童显着。由副交感神经活动低下组成的自主心血管调节特征代表了儿童肥胖发展的重要个体危险因素，但仅限于非裔美国儿童。讨论了早期生理调节困难可能导致儿童肥胖发生的机制。
The present study examined the role of cardiovascular regulation in predicting pediatric obesity. Participants for this study included 268 children (141 girls) obtained from a larger ongoing longitudinal study. To assess cardiac vagal regulation, resting measures of respiratory sinus arrhythmia (RSA) and RSA change (vagal withdrawal) to three cognitively challenging tasks were derived when children were 5.5 years of age. Heart period (HP) and HP change (heart rate (HR) acceleration) were also examined. Height and weight measures were collected when children were 5.5, 7.5, and 10.5 years of age. Results indicated that physiological regulation at age 5.5 was predictive of both normal variations in BMI development and pediatric obesity at age 10.5. Specifically, children with a cardiovascular regulation profile characterized by lower levels of RSA suppression and HP change experienced significantly greater levels of BMI growth and were more likely to be classified as overweight/at-risk for overweight at age 10.5 compared to children with a cardiovascular regulation profile characterized by high levels of RSA suppression and HP change. However, a significant interaction with racial status was found suggesting that the association between cardiovascular regulation profile and BMI growth and pediatric obesity was only significant for African-American children. An autonomic cardiovascular regulation profile consisting of low parasympathetic activity represents a significant individual risk factor for the development of pediatric obesity, but only for African-American children. Mechanisms by which early physiological regulation difficulties may contribute to the development of pediatric obesity are discussed.
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DOI：
10.1111/j.1540-5834.2009.00501.x
发表时间：
2009
影响因子：
9.5
作者：
El-Sheikh M;Kouros CD;Erath S;Cummings EM;Keller P;Staton L
通讯作者：
Staton L
影响因子：
4.9
作者：
Graziano, P. A.;Calkins, S. D.;Keane, S. P.
通讯作者：
Keane, S. P.
影响因子：
5.1
作者：
Gutin, B;Owens, S;Treiber, F
通讯作者：
Treiber, F
影响因子：
4.8
作者：
Lampert, R;Ickovics, J;Lee, F
通讯作者：
Lee, F
影响因子：
2.8
作者：
Nederkoorn, Chantal;Braet, Caroline;Jansen, Anita
通讯作者：
Jansen, Anita