Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia.
Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia.
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DOI：
10.1182/bloodadvances.2021004926
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发表时间：
2022-04-12
期刊：
影响因子：
7.5
通讯作者：
Sperling, Adam S.
中科院分区：
文献类型：
--
作者：
Tahri, Sabrin;Mouhieddine, Tarek H.;Redd, Robert;Lampe, Luisa;Nilsson, Katarina, I;El-Khoury, Habib;Su, Nang Kham;Nassar, Amin H.;Adib, Elio;Bindra, Govind;Abou Alaiwi, Sarah;Trippa, Lorenzo;Steensma, David P.;Castillo, Jorge J.;Treon, Steven P.;Ghobrial, Irene M.;Sperling, Adam S.
至少14%的WM患者存在克隆性造血。CH患者更可能从IgM MGUS或闷烧WM进展为症状性WM。克隆性造血（CH）与接受自体干细胞移植的非霍奇金淋巴瘤（NHL）和多发性骨髓瘤患者的不良结局相关。尽管如此，它对惰性NHL患者的影响还没有得到很好的研究。我们报告了华登斯特伦巨球蛋白血症（WM）患者中CH的患病率及其与临床结局的相关性。为了明确区分CH突变与WM克隆中的突变，CH被定义为DNMT3A、TET2或ASXL1（DTA）中存在体细胞突变，并在587例意义不明的IgM单克隆丙种球蛋白病（MGUS）、闷烧WM（SWM）或WM患者中检测到14%。DTA克隆的存在和大小与年龄较大有关。CH患者从MGUS或SWM进展为WM的风险增加，但在该队列中总生存率并不差。这些发现进一步阐明了CH在惰性NHL（如WM）患者中的临床效果。
Clonal hematopoiesis is present in at least 14% of patients with WM. Patients with CH are more likely to progress from IgM MGUS or smoldering WM to symptomatic WM. Clonal hematopoiesis (CH) is associated with adverse outcomes in patients with non-Hodgkin lymphoma (NHL) and multiple myeloma undergoing autologous stem cell transplantation. Still, its implications for patients with indolent NHL have not been well studied. We report the prevalence of CH in patients with Waldenström macroglobulinemia (WM) and its association with clinical outcomes. To unambiguously differentiate CH mutations from those in the WM clone, CH was defined by the presence of somatic mutations in DNMT3A, TET2, or ASXL1 (DTA) and was detected in 14% of 587 patients with IgM monoclonal gammopathy of undetermined significance (MGUS), smoldering WM (SWM) or WM. The presence and size of DTA clones were associated with older age. Patients with CH had an increased risk of progression from MGUS or SWM to WM, but not worse overall survival in this cohort. These findings further illuminate the clinical effects of CH in patients with indolent NHL such as WM.
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DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
在健康个体中预测急性髓样白血病的风险。
影响因子：
64.8
作者：
Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
通讯作者：
Shlush LI
影响因子：
2.7
作者：
Hanzis, Christina;Ojha, Rohit P.;Treon, Steven P.
通讯作者：
Treon, Steven P.
影响因子：
16.6
作者：
Mouhieddine, Tarek H.;Sperling, Adam S.;Ghobrial, Irene M.
通讯作者：
Ghobrial, Irene M.
DOI：
10.1056/nejmoa1701719
发表时间：
2017-07-13
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jaiswal S;Natarajan P;Silver AJ;Gibson CJ;Bick AG;Shvartz E;McConkey M;Gupta N;Gabriel S;Ardissino D;Baber U;Mehran R;Fuster V;Danesh J;Frossard P;Saleheen D;Melander O;Sukhova GK;Neuberg D;Libby P;Kathiresan S;Ebert BL
通讯作者：
Ebert BL