The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.
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DOI：
10.1016/j.brainresrev.2008.09.002
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发表时间：
2009-03
影响因子：
--
通讯作者：
Mattson MP
中科院分区：
文献类型：
--
作者：
Maalouf M;Rho JM;Mattson MP
热量限制和生酮饮食的治疗潜力已在临床环境和各种神经系统疾病动物模型中反复得到证实。其机制包括线粒体功能的改善、凋亡因子表达的减少和神经营养因子活性的增加。然而，生酮饮食的临床应用受到耐受性差和潜在严重副作用的严重阻碍。最近的研究旨在确定一种介质，可以重现热量限制的神经保护作用，对饮食摄入量的要求不高，表明酮体可能是一个合适的候选者。酮体保护神经元免受多种类型的神经元损伤，其潜在机制与热量限制和生酮饮食的机制相似。本文综述了热量限制、生酮饮食和酮体的神经保护作用，并比较了这些干预措施的分子作用机制。
The therapeutic potential of calorie restriction and the ketogenic diet have been repeatedly demonstrated in clinical settings and in various animal models of neurological disease. The underlying mechanisms involve an improvement in mitochondrial function, a decrease in the expression of apoptotic factors and an increase in the activity of neurotrophic factors. Clinical applications of ketogenic diets have been significantly hampered however by poor tolerability and potentially serious side-effects. Recent research aimed at identifying a mediator that can reproduce the neuroprotective effects of calorie restriction with less demanding changes to dietary intake suggests that ketone bodies might represent an appropriate candidate. Ketone bodies protect neurons against multiple types of neuronal injury and the underlying mechanisms are similar to those of calorie restriction and of the ketogenic diet. The present review describes the neuroprotective effects of calorie restriction, the ketogenic diet and ketone bodies and compare the molecular mechanisms of action of these interventions.
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影响因子：
9.8
作者：
Bordone L;Motta MC;Picard F;Robinson A;Jhala US;Apfeld J;McDonagh T;Lemieux M;McBurney M;Szilvasi A;Easlon EJ;Lin SJ;Guarente L
通讯作者：
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3.3
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DOI：
10.1093/gerona/61.7.675
发表时间：
2006-07-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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