Trichuris muris as a tool for holistic discovery research: from translational research to environmental bio-tagging.
Trichuris muris as a tool for holistic discovery research: from translational research to environmental bio-tagging.
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DOI：
10.1017/s003118202100069x
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发表时间：
2021-05-06
期刊：
影响因子：
2.4
通讯作者：
Forman R
中科院分区：
文献类型：
--
作者：
Mair I;Else KJ;Forman R
鞭虫属鞭虫（鞭虫）是肠线虫寄生虫，其引起与显著发病率相关的慢性感染。小鼠体内的鞭虫是鞭虫中研究得最充分的一种，对该物种的研究已经从许多不同的学科进行了探讨。对T.实验室小鼠体内的muris通过分析对感染的免疫反应，确定宿主易感性和抗性的基础因素，为宿主-寄生虫相互作用提供了重要的见解。实验室研究也为通过驱虫药和疫苗研究控制疾病的战略提供了信息。相反，对自然发生的鞭虫属感染的研究。允许分析宿主-寄生虫共同进化关系和寄生虫遗传多样性。此外，利用鞭虫的生态学研究有助于我们了解寄生虫、宿主和环境之间的复杂关系。最近，在野生和半野生环境中进行的研究将家鼠模式生物的优势与对感染的环境依赖性生理反应的复杂性结合起来。这篇评论庆祝鞭虫研究的受益者非常广泛，从免疫学家和寄生虫学家，通过流行病学家，生态学家和进化生物学家到兽医和医学界。
Trichuris spp. (whipworms) are intestinal nematode parasites which cause chronic infections associated with significant morbidities. Trichuris muris in a mouse is the most well studied of the whipworms and research on this species has been approached from a number of different disciplines. Research on T. muris in a laboratory mouse has provided vital insights into the host–parasite interaction through analyses of the immune responses to infection, identifying factors underpinning host susceptibility and resistance. Laboratory studies have also informed strategies for disease control through anthelmintics and vaccine research. On the contrary, research on naturally occurring infections with Trichuris spp. allows the analysis of the host–parasite co-evolutionary relationships and parasite genetic diversity. Furthermore, ecological studies utilizing Trichuris have aided our knowledge of the intricate relationships amongst parasite, host and environment. More recently, studies in wild and semi-wild settings have combined the strengths of the model organism of the house mouse with the complexities of context-dependent physiological responses to infection. This review celebrates the extraordinarily broad range of beneficiaries of whipworm research, from immunologists and parasitologists, through epidemiologists, ecologists and evolutionary biologists to the veterinary and medical communities.
影响因子：
2.2
作者：
Bradford BM;Donaldson DS;Forman R;Else KJ;Mabbott NA
通讯作者：
Mabbott NA