Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods.

Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods.
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DOI:
10.3390/metabo11060386
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发表时间:
2021-06-14
期刊:
影响因子:
4.1
通讯作者:
Gordon JW
Gordon JW
中科院分区:
生物学3区
文献类型:
--
作者:
Larson PEZ;Gordon JW

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Hyperpolarized metabolic MRI with C-labeled agents has emerged as a powerful technique for in vivo assessments of real-time metabolism that can be used across scales of cells, tissue slices, animal models, and human subjects. Hyperpolarized contrast agents have unique properties compared to conventional MRI scanning and MRI contrast agents that require specialized imaging methods. Hyperpolarized contrast agents have a limited amount of available signal, irreversible decay back to thermal equilibrium, bolus injection and perfusion kinetics, cellular uptake and metabolic conversion kinetics, and frequency shifts between metabolites. This article describes state-of-the-art methods for hyperpolarized metabolic MRI, summarizing data acquisition, reconstruction, and analysis methods in order to guide the design and execution of studies.
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