Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction.

Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction.
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DOI:
10.3389/fendo.2021.724632
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发表时间:
2021
影响因子:
5.2
通讯作者:
Tsukamura H
Tsukamura H
中科院分区:
医学2区
文献类型:
--
作者:
Uenoyama Y;Nagae M;Tsuchida H;Inoue N;Tsukamura H

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在过去二十年中积累的越来越多的证据表明,2001年发现的当时新的kisspeptin、分别于1983年和1979年发现的已知神经肽神经激肽B和强啡肽A及其G蛋白偶联受体是控制哺乳动物生殖的关键分子。本综述提供了一个简短的历史背景和总结我们最近的理解的作用下丘脑神经元表达kisspeptin,神经激肽B,强啡肽A,被称为KNDy神经元,在中枢机制下促性腺激素释放激素(GnRH)脉冲的产生和随后的紧张性促性腺激素释放,控制哺乳动物生殖。
Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and their G-protein-coupled receptors, serve as key molecules that control reproduction in mammals. The present review provides a brief historical background and a summary of our recent understanding of the roles of hypothalamic neurons expressing kisspeptin, neurokinin B, and dynorphin A, referred to as KNDy neurons, in the central mechanism underlying gonadotropin-releasing hormone (GnRH) pulse generation and subsequent tonic gonadotropin release that controls mammalian reproduction.
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