The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer
The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer
复制标题
甲酰基肽受体1基因多态性在人结直肠癌中的作用
DOI：
10.7150/jca.36355
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发表时间：
2020-03
影响因子：
3.9
通讯作者：
Ning Su
中科院分区：
文献类型：
--
作者：
Shu-Qin Li;Yang Yu;Yan Zhang;Yan-Ping Sun;Xin-xing Li;Ning Su
甲酰肽受体1（FPR 1）属于G蛋白偶联受体，主要表达于吞噬性白细胞。编码FPR 1的基因具有高度多态性，与炎症相关。本研究旨在探讨Fpr 1基因单核苷酸多态性（single nucleotide polymorphisms，SNPs）在结直肠癌（colorectal cancer，CRC）中的分布，并分析其与临床病理参数及CRC特异性诊断标志物的相关性。Fpr 1基因SNPs在结直肠癌组织中的等位基因频率和基因型频率与中国健康人全血中的频率无显著性差异。c.289C>A基因型与远处转移显著相关（P=0.001），c.306T>C基因型与肿瘤大小显著相关（P=0.016）。c.546C>A基因型与肿瘤大小和淋巴结转移关系密切（P=0.012和P=0.043）。同时，c.1037C>A基因型与肿瘤的部位和分化程度有关（分别为P=0.000和P=0.005）。此外，c.576T>C>G基因型与病理类型有关（P=0.000）。Fpr 1的c.289（C>A）和c.576（G>C>T）位点与P53的表达相关（分别为P=0.004和P=0.008），其他位点与CEA、HER 2和Ki-67的表达相关（P<0.05）。Fpr 1单核苷酸多态性可能在大肠癌的发生、发展和转移中起重要作用。
Formyl peptide receptor 1 (FPR1) belongs to G protein-coupled receptors expressed mainly in phagocytic leukocytes. The gene encoding FPR1 is highly polymorphic and related to inflammation. In this study, we investigated the single nucleotide polymorphisms (SNPs) of Fpr1 in human colorectal cancer (CRC), and analyzed the association of Fpr1 SNPs with clinicopathological parameters and some specific diagnostic markers of CRC. Although the allele and genotype frequencies of Fpr1 SNPs in CRC tissues were not significantly different from that in whole blood cells derived from healthy Chinese subjects. Significant associations were observed between genotypes of c.289C>A and distant metastasis (P=0.001), and between genotypes of c.306T>C and tumor size (P=0.016). Genotypes of c.546C>A was closer to tumor size and lymphatic invasion (P=0.012 and P=0.043, respectively). Meanwhile, genotypes of c.1037C>A was related with tumor location and differentiation (P=0.000 and P=0.005, respectively). Besides, genotypes of c.576T>C>G was related with pathological type (P=0.000). Furthermore, several Fpr1 SNP positions including c.289 (C>A) and c.576 (G>C>T) were related to the expression of P53 (P=0.004 and P=0.008, respectively), and similar results were observed between other Fpr1 SNP positions and CEA, HER2 and Ki-67 (P<0.05). Our data demonstrate that Fpr1 SNPs may play the important role in the progression and metastasis of CRC.
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DOI：
10.1016/b978-1-4160-3251-9.50008-x
发表时间：
2019-10
期刊：
The Lancet
影响因子：
--
作者：
E. Dekker;P. Tanis;J. Vleugels;P. Kasi;M. Wallace
通讯作者：
E. Dekker;P. Tanis;J. Vleugels;P. Kasi;M. Wallace
影响因子：
3.5
作者：
Zhai Cai;Shuai Han;Zhou Li;Lin-yun He;Jiajing Zhou;Wenhua Huang;Yichun Xu
通讯作者：
Zhai Cai;Shuai Han;Zhou Li;Lin-yun He;Jiajing Zhou;Wenhua Huang;Yichun Xu
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
168.9
作者：
Midgley, R;Kerr, D
通讯作者：
Kerr, D
DOI：
10.1016/j.bbrc.2010.12.136
发表时间：
2011-02
影响因子：
3.1
作者：
T. Otani;S. Ikeda;H. Lwin;T. Arai;M. Muramatsu;M. Sawabe
通讯作者：
T. Otani;S. Ikeda;H. Lwin;T. Arai;M. Muramatsu;M. Sawabe