Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease.
Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease.
复制标题
DOI：
10.1007/s00246-022-02891-3
复制
发表时间：
2022-10
影响因子：
1.6
通讯作者：
中科院分区：
文献类型：
--
作者：
先天性心脏病(CHD)是美国常见的出生缺陷。先天性心脏病婴儿更有可能有较小的头围和神经发育迟缓；然而，原因尚不清楚。脑血管血流动力学改变可能导致神经异常，如头围变小，因此我们创建了一个新的脑血管稳定指数(CSI)，作为脑自动调节的替代指标。我们假设CHD婴儿的CSI与头围之间存在关联。我们在CHD婴儿和健康对照组中进行了一项前瞻性的纵向研究。测量4个时间点(新生儿、3、6、9月)的CSI和头围。我们通过连续三次倾斜(0-90°)减去仰卧位脑氧合(RcSO2)的平均2分钟坐位来计算CSI，然后计算每个年龄的变化分数。线性回归量化了CSI和头围之间的关系。我们总共进行了177次评估(80名健康对照，97名CHD婴儿)。冠心病组婴儿的平均头围(39.2厘米)小于健康对照组(41.6厘米)(p<；0.001)，当结合所有时间点时，样本中总体上的CSI改善，头围增加了0.27厘米(p=0.04)。同样，随着先天性心脏病婴儿CSI的改善，头围增加了0.32厘米(p=0.04)。我们发现，在我们的样本中，CSI与头围显著相关，这表明CSI受损可能会影响CHD婴儿的大脑大小。未来的研究需要更好地理解CSI和脑发育之间的相互作用机制。
Congenital heart disease (CHD) is a common birth defect in the United States. CHD infants are more likely to have smaller head circumference and neurodevelopmental delays; however, the cause is unknown. Altered cerebrovascular hemodynamics may contribute to neurologic abnormalities, such as smaller head circumference, thus we created a novel Cerebrovascular Stability Index (CSI), as a surrogate for cerebral autoregulation. We hypothesized that CHD infants would have an association between CSI and head circumference. We performed a prospective, longitudinal study in CHD infants and healthy controls. We measured CSI and head circumference at 4 time points (newborn, 3, 6, 9 months). We calculated CSI by subtracting the average 2-min sitting from supine cerebral oxygenation (rcSO2) over three consecutive tilts (0–90°), then averaged the change score for each age. Linear regressions quantified the relationship between CSI and head circumference. We performed 177 assessments in total (80 healthy controls, 97 CHD infants). The average head circumference was smaller in CHD infants (39.2 cm) compared to healthy controls (41.6 cm) (p < 0.001) and head circumference increased by 0.27 cm as CSI improved in the sample (p = 0.04) overall when combining all time points. Similarly, head circumference increased by 0.32 cm as CSI improved among CHD infants (p = 0.04). We found CSI significantly associated with head circumference in our sample overall and CHD infants alone, which suggests that impaired CSI may affect brain size in CHD infants. Future studies are needed to better understand the mechanism of interaction between CSI and brain growth.
登录
查看更多内容
DOI：
10.1007/978-1-4939-0620-8_34
发表时间：
2014-01-01
期刊：
OXYGEN TRANSPORT TO TISSUE XXXVI
影响因子：
--
作者：
Endo, Ayumi;Fujita, Yukihiko;Skatani, Kaoru
通讯作者：
Skatani, Kaoru
影响因子：
5.1
作者：
Miller, Thomas A.;Zak, Victor;Williams, Richard V.
通讯作者：
Williams, Richard V.
影响因子：
8
作者：
Pellicer, A;Gayá, F;Cabañas, F
通讯作者：
Cabañas, F
影响因子：
3
作者：
Rajagopalan, Vidya;Votava-Smith, Jodie K.;Paquette, Lisa
通讯作者：
Paquette, Lisa
影响因子：
37.8
作者：
Limperopoulos C;Tworetzky W;McElhinney DB;Newburger JW;Brown DW;Robertson RL Jr;Guizard N;McGrath E;Geva J;Annese D;Dunbar-Masterson C;Trainor B;Laussen PC;du Plessis AJ
通讯作者：
du Plessis AJ