Target dependence of hypoglossal motor neurons during development and in maturity

Target dependence of hypoglossal motor neurons during development and in maturity
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舌下运动神经元在发育和成熟过程中的目标依赖性

DOI:
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发表时间:
1989
期刊:
The Journal of comparative neurology
影响因子:
--
通讯作者:
S. Thanedar
S. Thanedar
中科院分区:
--
文献类型:
--
作者:
W. Snider;S. Thanedar

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我们通过切断舌下神经和防止舌神经再支配的方法,研究了出生后大鼠舌下运动神经元的靶依赖性。出生后早期横断后,约60%的舌下运动神经元死亡,存活的神经元与对侧对照相比明显萎缩。在成熟期,也有大量的神经元萎缩,大约30%的运动神经元似乎在手术后死亡。然而,大多数成年人的舌下神经细胞在横断后存活长达1年。成虫的反应在3周龄时就出现了。
We have investigated the target dependence of hypoglossal motor neurons in postnatal rats by transecting the hypoglossal nerve and preventing reinnervation of the tongue. After transection in early postnatal life, approximately 60% of hypoglossal motor neurons die and surviving neurons are markedly atrophic compared to contralateral controls. In maturity, there is also substantial neuronal atrophy and about 30% of motor neurons appear to die after the procedure. However, most hypoglossal neurons in adults survive transection for periods up to 1 year. The adult response is present by 3 weeks of age.
DOI: 10.1073/pnas.83.23.9231
发表时间: 1986-12-01
影响因子: 11.1
作者:
WILLIAMS, LR;VARON, S;GAGE, FH
通讯作者: GAGE, FH
DOI: 10.1073/pnas.84.10.3472
发表时间: 1987-05-01
影响因子: 11.1
作者:
HOFFMAN, PN;CLEVELAND, DW;PRICE, DL
通讯作者: PRICE, DL
DOI: 10.1126/science.3798108
发表时间: 1987-01-09
期刊: SCIENCE
影响因子: 56.9
作者:
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通讯作者: KROMER, LF