Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010.
Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010.
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DOI：
10.1016/s0140-6736(13)61953-4
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发表时间：
2014-01-18
期刊：
影响因子：
168.9
通讯作者：
Murray, Christopher
中科院分区：
文献类型：
--
作者：
Feigin, Valery L.;Forouzanfar, Mohammad H.;Krishnamurthi, Rita;Mensah, George A.;Connor, Myles;Bennett, Derrick A.;Moran, Andrew E.;Sacco, Ralph L.;Anderson, Laurie;Truelsen, Thomas;O'Donnell, Martin;Venketasubramanian, Narayanaswamy;Barker-Collo, Suzanne;Lawes, Carlene M. M.;Wang, Wenzhi;Shinohara, Yukito;Witt, Emma;Ezzati, Majid;Naghavi, Mohsen;Murray, Christopher
尽管中风是全球第二大死亡原因，但尚未对大多数地区的发病率、患病率、死亡率、残疾和流行病学趋势进行全面和可比较的评估。我们使用 2010 年全球疾病、伤害和危险因素负担研究 (GBD 2010) 的数据来估计 1990 年至 2010 年期间的全球和区域卒中负担。我们检索了 1990 年至 2012 年的 Medline、Embase、LILACS、Scopus、PubMed、Science Direct、全球健康数据库、WHO 图书馆和 WHO 区域数据库，以确定 1990 年至 2010 年间发表的相关研究。我们应用 GBD 2010 分析技术 (DisMod-MR)，基于特定疾病、预先指定的发病率、患病率和死亡率之间的关联，来计算区域和国家特定的卒中估计值1990 年、2005 年和 2010 年按年龄组（<75 岁、≥75 岁和总计）和国家收入水平（高收入、低收入和中等收入）划分的发病率、患病率、死亡率和伤残调整生命年 (DALY) 损失。我们纳入了 119 项研究（58 项来自高收入国家，61 项来自低收入和中等收入国家）。从 1990 年到 2010 年，高收入国家的年龄标准化卒中发病率显着下降了 12%（95% CI 6-17），而低收入和中等收入国家则上升了 12%（–3 至 22），尽管增幅并不显着。高收入国家（37%，31-41）以及低收入和中等收入国家（20%，15-30）的死亡率均显着下降。 2010年，首次中风患者（16·900万）、中风幸存者（3300万）、中风相关死亡（5·900万）和伤残调整生命年（1.02亿）的绝对数量很高，并且自1990年以来显着增加（分别增加68％、84％、26％和12％），其中大部分负担（中风发生率68·6％，流行率52·2％）在低收入和中等收入国家，中风、70·9% 的中风死亡和 77·7% 的伤残调整生命年 (DALY) 损失）。 2010年，儿童（年龄<20岁）和青壮年（20-64岁）中有5·2百万（31％）中风，其中来自低收入和中等收入国家的儿童和青壮年分别贡献了近74 000（89％）和4·0百万（78％）的负担。此外，我们注意到 GBD 地区和国家之间的卒中负担存在显着的地理差异，差异为三到十倍。超过 62% 的新发中风、69·8% 的流行中风、45·5% 的中风死亡以及 71·7% 的因中风导致的伤残调整生命年 (DALY) 发生在 75 岁以下的人群中。尽管在过去二十年里，全球范围内年龄标准化的中风死亡率有所下降，但每年中风的绝对人数、中风幸存者、相关死亡人数以及全球中风总体负担（伤残调整生命年（DALYs）损失）仍然很大，而且还在不断增加。需要进一步研究以增进对全球卒中决定因素和负担的了解，并确定不同收入水平国家之间卒中负担趋势差异的原因和变化。比尔及梅琳达·盖茨基金会。
Although stroke is the second leading cause of death worldwide, no comprehensive and comparable assessment of incidence, prevalence, mortality, disability, and epidemiological trends has been estimated for most regions. We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to estimate the global and regional burden of stroke during 1990–2010. We searched Medline, Embase, LILACS, Scopus, PubMed, Science Direct, Global Health Database, the WHO library, and WHO regional databases from 1990 to 2012 to identify relevant studies published between 1990 and 2010. We applied the GBD 2010 analytical technique (DisMod-MR), based on disease-specific, pre-specified associations between incidence, prevalence, and mortality, to calculate regional and country-specific estimates of stroke incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) lost by age group (<75 years, ≥75 years, and in total) and country income level (high-income, and low-income and middle-income) for 1990, 2005, and 2010. We included 119 studies (58 from high-income countries and 61 from low-income and middle-income countries). From 1990 to 2010, the age-standardised incidence of stroke significantly decreased by 12% (95% CI 6–17) in high-income countries, and increased by 12% (–3 to 22) in low-income and middle-income countries, albeit non-significantly. Mortality rates decreased significantly in both high income (37%, 31–41) and low-income and middle-income countries (20%, 15–30). In 2010, the absolute numbers of people with first stroke (16·9 million), stroke survivors (33 million), stroke-related deaths (5·9 million), and DALYs lost (102 million) were high and had significantly increased since 1990 (68%, 84%, 26%, and 12% increase, respectively), with most of the burden (68·6% incident strokes, 52·2% prevalent strokes, 70·9% stroke deaths, and 77·7% DALYs lost) in low-income and middle-income countries. In 2010, 5·2 million (31%) strokes were in children (aged <20 years old) and young and middle-aged adults (20–64 years), to which children and young and middle-aged adults from low-income and middle-income countries contributed almost 74 000 (89%) and 4·0 million (78%), respectively, of the burden. Additionally, we noted significant geographical differences of between three and ten times in stroke burden between GBD regions and countries. More than 62% of new strokes, 69·8% of prevalent strokes, 45·5% of deaths from stroke, and 71·7% of DALYs lost because of stroke were in people younger than 75 years. Although age-standardised rates of stroke mortality have decreased worldwide in the past two decades, the absolute number of people who have a stroke every year, stroke survivors, related deaths, and the overall global burden of stroke (DALYs lost) are great and increasing. Further study is needed to improve understanding of stroke determinants and burden worldwide, and to establish causes of disparities and changes in trends in stroke burden between countries of different income levels. Bill & Melinda Gates Foundation.
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影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
8.3
作者：
Andre, Charles;Curioni, Cintia Chaves;Veras, Renato
通讯作者：
Veras, Renato
影响因子：
8.3
作者：
Medin, J;Nordlund, A;Ekberg, K
通讯作者：
Ekberg, K
影响因子：
168.9
作者：
Lim, Stephen S.;Vos, Theo;Flaxman, Abraham D.;Danaei, Goodarz;Shibuya, Kenji;Adair-Rohani, Heather;Amann, Markus;Anderson, H. Ross;Andrews, Kathryn G.;Aryee, Martin;Atkinson, Charles;Bacchus, Loraine J.;Bahalim, Adil N.;Balakrishnan, Kalpana;Balmes, John;Barker-Collo, Suzanne;Baxter, Amanda;Bell, Michelle L.;Blore, Jed D.;Blyth, Fiona;Bonner, Carissa;Borges, Guilherme;Bourne, Rupert;Boussinesq, Michel;Brauer, Michael;Brooks, Peter;Bruce, Nigel G.;Brunekreef, Bert;Bryan-Hancock, Claire;Bucello, Chiara;Buchbinder, Rachelle;Bull, Fiona;Burnett, Richard T.;Byers, Tim E.;Calabria, Bianca;Carapetis, Jonathan;Carnahan, Emily;Chafe, Zoe;Charlson, Fiona;Chen, Honglei;Chen, Jian Shen;Cheng, Andrew Tai-Ann;Child, Jennifer Christine;Cohen, Aaron;Colson, K. Ellicott;Cowie, Benjamin C.;Darby, Sarah;Darling, Susan;Davis, Adrian;Degenhardt, Louisa;Dentener, Frank;Des Jarlais, Don C.;Devries, Karen;Dherani, Mukesh;Ding, Eric L.;Dorsey, E. Ray;Driscoll, Tim;Edmond, Karen;Ali, Suad Eltahir;Engell, Rebecca E.;Erwin, Patricia J.;Fahimi, Saman;Falder, Gail;Farzadfar, Farshad;Ferrari, Alize;Finucane, Mariel M.;Flaxman, Seth;Fowkes, Francis Gerry R.;Freedman, Greg;Freeman, Michael K.;Gakidou, Emmanuela;Ghosh, Santu;Giovannucci, Edward;Gmel, Gerhard;Graham, Kathryn;Grainger, Rebecca;Grant, Bridget;Gunnell, David;Gutierrez, Hialy R.;Hall, Wayne;Hoek, Hans W.;Hogan, Anthony;Hosgood, H. Dean, III;Hoy, Damian;Hu, Howard;Hubbell, Bryan J.;Hutchings, Sally J.;Ibeanusi, Sydney E.;Jacklyn, Gemma L.;Jasrasaria, Rashmi;Jonas, Jost B.;Kan, Haidong;Kanis, John A.;Kassebaum, Nicholas;Kawakami, Norito;Khang, Young-Ho;Khatibzadeh, Shahab;Khoo, Jon-Paul;Kok, Cindy;Laden, Francine;Lalloo, Ratilal;Lan, Qing;Lathlean, Tim;Leasher, Janet L.;Leigh, James;Li, Yang;Lin, John Kent;Lipshultz, Steven E.;London, Stephanie;Lozano, Rafael;Lu, Yuan;Mak, Joelle;Malekzadeh, Reza;Mallinger, Leslie;Marcenes, Wagner;March, Lyn;Marks, Robin;Martin, Randall;McGale, Paul;McGrath, John;Mehta, Sumi;Mensah, George A.;Merriman, Tony R.;Micha, Renata;Michaud, Catherine;Mishra, Vinod;Hanafiah, Khayriyyah Mohd;Mokdad, Ali A.;Morawska, Lidia;Mozaffarian, Dariush;Murphy, Tasha;Naghavi, Mohsen;Neal, Bruce;Nelson, Paul K.;Miquel Nolla, Joan;Norman, Rosana;Olives, Casey;Omer, Saad B.;Orchard, Jessica;Osborne, Richard;Ostro, Bart;Page, Andrew;Pandey, Kiran D.;Parry, Charles D. H.;Passmore, Erin;Patra, Jayadeep;Pearce, Neil;Pelizzari, Pamela M.;Petzold, Max;Phillips, Michael R.;Pope, Dan;Pope, C. Arden, III;Powles, John;Rao, Mayuree;Razavi, Homie;Rehfuess, Eva A.;Rehm, Juergen T.;Ritz, Beate;Rivara, Frederick P.;Roberts, Thomas;Robinson, Carolyn;Rodriguez-Portales, Jose A.;Romieu, Isabelle;Room, Robin;Rosenfeld, Lisa C.;Roy, Ananya;Rushton, Lesley;Salomon, Joshua A.;Sampson, Uchechukwu;Sanchez-Riera, Lidia;Sanman, Ella;Sapkota, Amir;Seedat, Soraya;Shi, Peilin;Shield, Kevin;Shivakoti, Rupak;Singh, Gitanjali M.;Sleet, David A.;Smith, Emma;Smith, Kirk R.;Stapelberg, Nicolas J. C.;Steenland, Kyle;Stoeckl, Heidi;Stovner, Lars Jacob;Straif, Kurt;Straney, Lahn;Thurston, George D.;Tran, Jimmy H.;Van Dingenen, Rita;van Donkelaar, Aaron;Veerman, J. Lennert;Vijayakumar, Lakshmi;Weintraub, Robert;Weissman, Myrna M.;White, Richard A.;Whiteford, Harvey;Wiersma, Steven T.;Wilkinson, James D.;Williams, Hywel C.;Williams, Warwick;Wilson, Nicholas;Woolf, Anthony D.;Yip, Paul;Zielinski, Jan M.;Lopez, Alan D.;Murray, Christopher J. L.;Ezzati, Majid
通讯作者：
Ezzati, Majid
DOI：
10.1016/s0140-6736(10)62037-5
发表时间：
2011-02-12
期刊：
Lancet (London, England)
影响因子：
--
作者：
Finucane MM;Stevens GA;Cowan MJ;Danaei G;Lin JK;Paciorek CJ;Singh GM;Gutierrez HR;Lu Y;Bahalim AN;Farzadfar F;Riley LM;Ezzati M;Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
通讯作者：
Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)