Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.
Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.
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内质网氨基肽酶在健康和疾病中的作用：从感染到癌症。
DOI：
10.3390/ijms13078338
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发表时间：
2012
影响因子：
5.6
通讯作者：
Fruci D
中科院分区：
文献类型：
--
作者：
Cifaldi L;Romania P;Lorenzi S;Locatelli F;Fruci D
内质网（ER）氨基肽酶ERAP1和ERAP2 （ERAPs）对于参与各种生物过程的广泛蛋白质的成熟至关重要。在内质网中，这些酶协同工作以修剪肽以呈现在MHC I类分子上。ERAPs功能的丧失极大地改变了MHC I类分子呈现的肽库，严重影响NK和CD8+ T细胞的识别。此外，这些酶通过促进几种细胞因子受体的脱落参与炎症反应的调节，并参与血压和血管生成的调节。最近的全基因组关联研究已经确定了ERAP1和ERAP2的常见变异与几种人类疾病有关，从病毒感染到自身免疫和癌症。最近，ER肽修剪的抑制已被证明在刺激先天和适应性抗肿瘤免疫反应中发挥关键作用，这表明抑制ERAPs可能被用于建立针对癌症的创新治疗方法。本文综述了ERAP酶在内质网肽修剪和其他免疫和非免疫功能方面的现有资料，并重点介绍了这些酶在人类疾病中的新作用。
Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are essential for the maturation of a wide spectrum of proteins involved in various biological processes. In the ER, these enzymes work in concert to trim peptides for presentation on MHC class I molecules. Loss of ERAPs function substantially alters the repertoire of peptides presented by MHC class I molecules, critically affecting recognition of both NK and CD8+ T cells. In addition, these enzymes are involved in the modulation of inflammatory responses by promoting the shedding of several cytokine receptors, and in the regulation of both blood pressure and angiogenesis. Recent genome-wide association studies have identified common variants of ERAP1 and ERAP2 linked to several human diseases, ranging from viral infections to autoimmunity and cancer. More recently, inhibition of ER peptide trimming has been shown to play a key role in stimulating innate and adaptive anti-tumor immune responses, suggesting that inhibition of ERAPs might be exploited for the establishment of innovative therapeutic approaches against cancer. This review summarizes data currently available for ERAP enzymes in ER peptide trimming and in other immunological and non-immunological functions, paying attention to the emerging role played by these enzymes in human diseases.
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影响因子：
2.1
作者：
Hallberg P;Lind L;Michaëlsson K;Kurland L;Kahan T;Malmqvist K;Ohman KP;Nyström F;Liljedahl U;Syvänen AC;Melhus H
通讯作者：
Melhus H
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Beninga, J;Rock, KL;Goldberg, AL
通讯作者：
Goldberg, AL
影响因子：
3.7
作者：
Guerini FR;Cagliani R;Forni D;Agliardi C;Caputo D;Cassinotti A;Galimberti D;Fenoglio C;Biasin M;Asselta R;Scarpini E;Comi GP;Bresolin N;Clerici M;Sironi M
通讯作者：
Sironi M
影响因子：
--
作者：
Davidson, Stuart I.;Wu, Xin;Xu, Huji
通讯作者：
Xu, Huji