Individual Differences in Different Measures of Opioid Self-Administration in Rats Are Accounted for by a Single Latent Variable.
Individual Differences in Different Measures of Opioid Self-Administration in Rats Are Accounted for by a Single Latent Variable.
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DOI：
10.3389/fpsyt.2021.712163
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发表时间：
2021
影响因子：
4.7
通讯作者：
Harris AC
中科院分区：
文献类型：
--
作者：
Swain Y;Waller NG;Gewirtz JC;Harris AC
通过因子分析（FA）对人类成瘾脆弱性的个体差异进行了广泛研究，这是一种识别“潜在”变量（不能直接测量的变量）的统计方法，这些变量反映了大量观察到的测量结果中的共同方差。尽管FA在行为遗传学中广泛应用，但尚未用于临床前阿片类药物成瘾研究。本研究采用FA检测大鼠静脉注射吗啡自我给药（MSA）的四项指标（获取、需求弹性、吗啡/提示和应激/提示诱导恢复）的潜在因子结构。在临床前文献中，所有四种MSA测量通常被认为反映了“成瘾脆弱性”，在一些人类研究中，滥用责任的多种测量方法中的个体差异最好由一个潜在因素来解释。因此，对数据进行了单因素模型拟合。两个不同的正则化FAs表明单因素模型很好地拟合了我们的数据。获得性、需求弹性和吗啡/线索诱导的恢复显著地加载到单个潜在因素上，而应激/线索诱导的恢复则没有。与一些人类研究的结果一致，我们的研究结果表明，阿片类药物SA的几种测量方法背后存在一种常见的药物“成瘾”因素。然而，应激/线索诱导的恢复对这一因素的负荷很低，这表明独特的机制介导了这种与其他MSA测量的个体差异。进一步在药物SA和临床前神经精神病理学中建立FA方法，将为进一步的遗传分析提供更可靠、临床相关的动物模型疾病易感性基础核心因素。
Individual differences in vulnerability to addiction have been widely studied through factor analysis (FA) in humans, a statistical method that identifies “latent” variables (variables that are not measured directly) that reflect the common variance among a larger number of observed measures. Despite its widespread application in behavioral genetics, FA has not been used in preclinical opioid addiction research. The current study used FA to examine the latent factor structure of four measures of i.v. morphine self-administration (MSA) in rats (i.e., acquisition, demand elasticity, morphine/cue- and stress/cue-induced reinstatement). All four MSA measures are generally assumed in the preclinical literature to reflect “addiction vulnerability,” and individual differences in multiple measures of abuse liability are best accounted for by a single latent factor in some human studies. A one-factor model was therefore fitted to the data. Two different regularized FAs indicated that a one-factor model fit our data well. Acquisition, elasticity of demand and morphine/cue-induced reinstatement loaded significantly onto a single latent factor while stress/cue-induced reinstatement did not. Consistent with findings from some human studies, our results indicated a common drug “addiction” factor underlying several measures of opioid SA. However, stress/cue-induced reinstatement loaded poorly onto this factor, suggesting that unique mechanisms mediate individual differences in this vs. other MSA measures. Further establishing FA approaches in drug SA and in preclinical neuropsychopathology more broadly will provide more reliable, clinically relevant core factors underlying disease vulnerability in animal models for further genetic analyses.
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影响因子：
2.6
作者：
Hicks, Brian M.;Schalet, Benjamin D.;Malone, Stephen M.;Iacono, William G.;McGue, Matt
通讯作者：
McGue, Matt
影响因子：
6
作者：
Gillespie, Nathan A.;Neale, Michael C.;Kendler, Kenneth S.
通讯作者：
Kendler, Kenneth S.
影响因子：
1.5
作者：
de Winter, J. C. F.;Dodou, D.
通讯作者：
Dodou, D.
DOI：
10.1098/rspa.1931.0209
发表时间：
1931-12-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-CONTAINING PAPERS OF A MATHEMATICAL AND PHYSICAL CHARACTER
影响因子：
--
作者：
Heywood, HB
通讯作者：
Heywood, HB
影响因子：
5.4
作者：
Jung, Sunho;Lee, Soonmook
通讯作者：
Lee, Soonmook