Communication in the heart: the role of the innate immune system in coordinating cellular responses to ischemic injury.
Communication in the heart: the role of the innate immune system in coordinating cellular responses to ischemic injury.
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DOI：
10.1007/s12265-012-9410-7
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发表时间：
2012-12
影响因子：
3.4
通讯作者：
Mann, Douglas L.
中科院分区：
文献类型：
--
作者：
Epelman, Slava;Mann, Douglas L.
在美国，缺血性心脏损伤是导致心力衰竭和死亡的主要原因，也是医疗保健系统的主要费用。一旦心脏受到损伤，就会启动一种高度动态和协调的免疫反应，这依赖于常驻和招募的白细胞。炎症反应的目的是清除缺血和坏死物质，促进梗塞愈合。如果这一系统受到干扰，心肌愈合不良，导致严重的左心功能不全。在设计针对病理过程的治疗干预措施之前，需要了解炎症细胞如何协调和相互作用，并保持那些具有保护性的过程不受影响。这篇综述将讨论心肌缺血损伤后天然免疫系统细胞间的相互作用，以及这种反应是如何随着时间的推移而协调的。
Ischemic cardiac injury is the leading cause of heart failure and mortality in the US, and a major expense to health care systems. Once the heart is injured, a highly dynamic and coordinated immune response is initiated, which is dependent on both resident and recruited leukocytes. The goal of the inflammatory response is to remove ischemic and necrotic material, and to promote infarct healing. If this system is perturbed, the myocardium heals poorly, leading to significant left ventricular dysfunction. Understanding how inflammatory cells coordinate and interact with each other is required prior to designing therapeutic interventions that target pathological processes at play, and leave untouched those processes that are protective. This review will discuss the intercellular cross talk between cells of the innate immune system following myocardial ischemic injury and how that response is coordinated over time.
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DOI：
10.2353/ajpath.2010.090759
发表时间：
2010-05
期刊：
The American journal of pathology
影响因子：
--
作者：
Dobaczewski M;Xia Y;Bujak M;Gonzalez-Quesada C;Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
15.9
作者：
Fadok, VA;Bratton, DL;Henson, PM
通讯作者：
Henson, PM
影响因子：
82.9
作者：
Jonsson, H;Allen, P;Peng, SL
通讯作者：
Peng, SL
影响因子：
37.8
作者：
Hofmann, Ulrich;Beyersdorf, Niklas;Frantz, Stefan
通讯作者：
Frantz, Stefan
影响因子：
4.8
作者：
JOLLY, SR;KANE, WJ;LUCCHESI, BR
通讯作者：
LUCCHESI, BR