The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers
The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers
复制标题
NMDA 部分激动剂 D-环丝氨酸刺激健康志愿者的 LH 分泌
作者：
B. V. van Berckel;C. Lipsch;C. Gispen;H. Wynne;M. Blankenstein;J. van Ree;R. Kahn
D-Cycloserine, a partial agonist of the glycine recognition site of the N-methyl-D-aspartate (NMDA) receptor, may serve as a probe for human cerebral NMDA receptor function. Since NMDA receptors are involved in neuroendocrine secretion, changes in pituitary secretion in response to D-cycloserine administration could serve as a model for NMDA receptor activity. The effects of an oral dose of 500 mg D-cycloserine were assessed in a neuroendocrine challenge paradigm in 20 healthy male volunteers, using a double-blind, randomized placebo-controlled crossover design. Luteinizing hormone (LH) and cortisol secretion was studied, since preclinical studies indicate that these hormones increase in response to NMDA receptor stimulation. Furthermore, plasma homovanillic acid (HVA) secretion was studied, as NMDA receptors are suggested to be involved in the regulation of dopaminergic neurotransmission. D-cycloserine was readily absorbed and did not induce side-effects or changes in vital signs and mood scores. D-Cycloserine stimulated LH secretion and induced a significant rise of the area under the plasma concentration time curve of LH. D-Cycloserine did not stimulate cortisol or plasma HVA secretion. These neuroendocrine effects suggest that D-cycloserine may be used to assess human NMDA receptor function in cerebral disorders, such as schizophrenia.
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影响因子：
--
作者：
Guochuan Tsai;L. Passani;Barbara S. Slusher;R. E. Carter;Lee Baer;J. Kleinman;Joseph T. Coyle
通讯作者：
Guochuan Tsai;L. Passani;Barbara S. Slusher;R. E. Carter;Lee Baer;J. Kleinman;Joseph T. Coyle
N-甲基-D-天冬氨酸的表征和可能的阿片类药物调节可诱导发育中的雄性大鼠血清黄体生成素水平增加。
影响因子：
6.1
作者：
Cicero,TJ;Meyer,ER;Bell,RD
通讯作者：
Bell,RD
男性α亚基分泌的性质：昼夜节律、脉动释放和分泌特征。
影响因子：
--
作者：
Veldhuis,JD;Winters,SJ
通讯作者：
Winters,SJ
DOI：
10.1176/ajp.151.8.1234
发表时间：
1994-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Daniel C. Javitt;I. Zylberman;Stephen R. Zukin;U. Heresco-Levy;J. Lindenmayer
通讯作者：
Daniel C. Javitt;I. Zylberman;Stephen R. Zukin;U. Heresco-Levy;J. Lindenmayer
NMDA 和非 NMDA 受体拮抗剂对成年雄性大鼠脉动黄体生成素分泌的影响。
影响因子：
4.1
作者：
Ping,L;Mahesh,VB;Brann,DW
通讯作者：
Brann,DW