Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines.
Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines.
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DOI：
10.3390/vaccines8040574
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发表时间：
2020-10-01
期刊：
影响因子：
7.8
通讯作者：
Mittal SK
中科院分区：
文献类型：
--
作者：
Sayedahmed EE;Elkashif A;Alhashimi M;Sambhara S;Mittal SK
自从发现疫苗以来，许多致命疾病在世界范围内得到控制，最终消灭了天花和脊髓灰质炎，这是人类健康方面的重大医学成就。然而，这并没有说明流感对公共卫生构成的威胁。目前获得许可的季节性流感疫苗主要提供优异的毒株特异性保护。除了季节性流感病毒之外，禽流感大流行性病毒如H5N1、H7N9、H7N7和H9N2的出现和向人类的传播突出了对流感大流行采取新的全球准备的迫切需要。至关重要的是探索新的战略，以开发针对大流行性和季节性流感病毒的有效疫苗。新的疫苗方法应提供持久和广泛的保护，并有能力在短时间内大规模生产疫苗。基于腺病毒（Ad）载体的疫苗平台提供了一个强大的不依赖于鸡蛋的生产系统，用于在短时间内廉价地生产大量流感疫苗。本文就腺病毒载体流感疫苗的研究进展及其在设计通用流感疫苗中的应用前景进行综述。
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health. However, this does not account for the threat influenza poses on public health. The currently licensed seasonal influenza vaccines primarily confer excellent strain-specific protection. In addition to the seasonal influenza viruses, the emergence and spread of avian influenza pandemic viruses such as H5N1, H7N9, H7N7, and H9N2 to humans have highlighted the urgent need to adopt a new global preparedness for an influenza pandemic. It is vital to explore new strategies for the development of effective vaccines for pandemic and seasonal influenza viruses. The new vaccine approaches should provide durable and broad protection with the capability of large-scale vaccine production within a short time. The adenoviral (Ad) vector-based vaccine platform offers a robust egg-independent production system for manufacturing large numbers of influenza vaccines inexpensively in a short timeframe. In this review, we discuss the progress in the development of Ad vector-based influenza vaccines and their potential in designing a universal influenza vaccine.
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影响因子：
5.5
作者：
Boyd, Amy C.;Ruiz-Hernandez, Raul;Peroval, Marylene Y.;Carson, Connor;Balkissoon, Devanand;Staines, Karen;Turner, Alison V.;Hill, Adrian V. S.;Gilbert, Sarah C.;Butter, Colin
通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1038/mt.2013.284
发表时间：
2014-03
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
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作者：
通讯作者：
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影响因子：
3.8
作者：
Cohen, CJ;Xiang, ZQ;Bergelson, JM
通讯作者：
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