Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies.
Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies.
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DOI：
10.4254/wjh.v13.i2.166
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发表时间：
2021-02-27
影响因子：
2.4
通讯作者：
Mercea V
中科院分区：
文献类型：
--
作者：
Tantau AI;Mandrutiu A;Pop A;Zaharie RD;Crisan D;Preda CM;Tantau M;Mercea V
晚期或不能手术切除的肝外胆管癌预后差。超过50%的黄疸患者在首次诊断时无法手术。梗阻性黄疸患者的内镜治疗可确保术前或姑息性胆管引流。缓解症状（疼痛、瘙痒、黄疸）和改善生活质量是姑息治疗的目的。内镜下逆行胰胆管造影支架植入术通常是长期姑息治疗的首选方法。有各种各样的塑料和金属支架，覆盖或未覆盖。支架的选择取决于预期的生存时间、生活质量、成本和医生的专业知识。本文将为肝外胆管癌的内镜微创治疗提供一个框架。此外，其他治疗，如近距离放射治疗，光动力治疗，射频消融，化疗，分子靶向治疗和/或免疫治疗的内窥镜方法，是与生存率提高和/或局部症状缓解相关的非手术方法。
The prognosis of patients with advanced or unresectable extrahepatic cholangiocarcinoma is poor. More than 50% of patients with jaundice are inoperable at the time of first diagnosis. Endoscopic treatment in patients with obstructive jaundice ensures bile duct drainage in preoperative or palliative settings. Relief of symptoms (pain, pruritus, jaundice) and improvement in quality of life are the aims of palliative therapy. Stent implantation by endoscopic retrograde cholangiopancreatography is generally preferred for long-term palliation. There is a vast variety of plastic and metal stents, covered or uncovered. The stent choice depends on the expected length of survival, quality of life, costs and physician expertise. This review will provide the framework for the endoscopic minimally invasive therapy in extrahepatic cholangiocarcinoma. Moreover, additional therapies, such as brachytherapy, photodynamic therapy, radiofrequency ablation, chemotherapy, molecular-targeted therapy and/or immunotherapy by the endoscopic approach, are the nonsurgical methods associated with survival improvement rate and/or local symptom palliation.
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影响因子：
2.4
作者：
Liberato MJ;Canena JM
通讯作者：
Canena JM
影响因子：
14
作者：
Bae, Byoung-chan;Yang, Su-Geun;Reddy, D. Nageshwar
通讯作者：
Reddy, D. Nageshwar
影响因子：
6
作者：
Bapaye, Amol;Dubale, Nachiket;Aher, Advay
通讯作者：
Aher, Advay
DOI：
10.1038/nrgastro.2011.131
发表时间：
2011-08-02
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.6
作者：
Farges, O.;Regimbeau, J. M.;Gigot, J. F.
通讯作者：
Gigot, J. F.