Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective.
Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective.
复制标题
DOI：
10.1007/s12195-014-0357-4
复制
发表时间：
2014-12
影响因子：
2.8
通讯作者：
Alevriadou, B. Rita
中科院分区：
文献类型：
--
作者：
Scheitlin, Christopher G.;Nair, Devi M.;Crestanello, Juan A.;Zweier, Jay L.;Alevriadou, B. Rita
关键词：
内皮细胞功能障碍是每种心血管疾病/病症的标志，包括动脉粥样硬化和缺血/再灌注损伤。已知作用于血管内皮的流体剪切应力调节细胞稳态。血流动力学改变被认为在内皮功能障碍中起着致病作用。功能障碍与线粒体氧化应激相关/之前。我们小组和其他人的研究表明，当内皮细胞在存在或不存在额外的物理化学刺激的情况下暴露于剪切应力时，线粒体网络的形式和/或功能受到影响。本文综述了细胞内Ca ~（2+）-一氧化氮-线粒体活性氧、线粒体融合/分裂、自噬/线粒体自噬以及细胞凋亡与存活之间的相互关系。更具体地说，它将列出在生理流动条件下或在再灌注期间（缺血一段时间后）通过作用于内皮的流体剪切应力对上述细胞内物质和过程进行潜在调节的证据。了解局部血流动力学如何影响线粒体生理学和细胞氧化还原状态可能会导致开发新的治疗策略，用于预防或治疗内皮功能障碍，因此，心血管疾病。
Endothelial cell dysfunction is the hallmark of every cardiovascular disease/condition, including atherosclerosis and ischemia/reperfusion injury. Fluid shear stress acting on the vascular endothelium is known to regulate cell homeostasis. Altered hemodynamics is thought to play a causative role in endothelial dysfunction. The dysfunction is associated with/preceded by mitochondrial oxidative stress. Studies by our group and others have shown that the form and/or function of the mitochondrial network are affected when endothelial cells are exposed to shear stress in the absence or presence of additional physicochemical stimuli. The present review will summarize the current knowledge on the interconnections among intracellular Ca2+ - nitric oxide - mitochondrial reactive oxygen species, mitochondrial fusion/fission, autophagy/mitophagy, and cell apoptosis vs. survival. More specifically, it will list the evidence on potential regulation of the above intracellular species and processes by the fluid shear stress acting on the endothelium under either physiological flow conditions or during reperfusion (following a period of ischemia). Understanding how the local hemodynamics affects mitochondrial physiology and the cell redox state may lead to development of novel therapeutic strategies for prevention or treatment of the endothelial dysfunction and, hence, of cardiovascular disease.
登录
查看更多内容
影响因子：
7.4
作者：
Dodson, Matthew;Darley-Usmar, Victor;Zhang, Jianhua
通讯作者：
Zhang, Jianhua
DOI：
10.1152/ajpheart.00717.2011
发表时间：
2012-02-01
影响因子：
4.8
作者：
Bubolz, Aaron H.;Mendoza, Suelhem A.;Zhang, David X.
通讯作者：
Zhang, David X.
影响因子：
20.1
作者：
Bentzon, Jacob Fog;Otsuka, Fumiyuki;Falk, Erling
通讯作者：
Falk, Erling
影响因子：
7.7
作者：
Cribbs, J. Thomas;Strack, Stefan
通讯作者：
Strack, Stefan
DOI：
10.1152/ajpheart.00742.2003
发表时间：
2004-01-01
影响因子：
4.8
作者：
Brookes, PS;Darley-Usmar, VM
通讯作者：
Darley-Usmar, VM