A longitudinal study of depression, fatigue, and sleep disturbances as a symptom cluster in women with breast cancer.
A longitudinal study of depression, fatigue, and sleep disturbances as a symptom cluster in women with breast cancer.
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DOI：
10.1016/j.jpainsymman.2014.09.009
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发表时间：
2015-04
影响因子：
4.7
通讯作者：
McKinley PS
中科院分区：
文献类型：
--
作者：
Ho SY;Rohan KJ;Parent J;Tager FA;McKinley PS
抑郁、疲劳和睡眠障碍已被确定为乳腺癌患者的一组症状。然而，很少有纵向研究探讨了这些症状之间的时间关系周围的诊断和治疗。目前的研究调查了乳腺癌患者在三个时间点的非躯体抑郁症状，疲劳和睡眠障碍的共同发生和相互关系：辅助化疗治疗前，后和6至8个月后。绝经前（N = 67）和绝经后（N = 67）乳腺癌患者的单独样本在所有三个时间点完成了抑郁，疲劳和睡眠障碍的自我报告措施。路径分析用于探索跨时间的症状内和症状间路径。抑郁、疲劳和睡眠障碍在每个时间点内都有相关性。连续性路径，即先前的症状严重程度水平往往预测随后的严重程度相同的症状在随后的时间点，是显着的，在两个样本中，除了抑郁症的绝经前样本。相反，出现了显著的交叉症状路径，即基线疲劳预测化疗后抑郁，化疗后疲劳预测绝经前患者随访时的抑郁。绝经后样本没有出现显著的交叉症状路径。研究结果支持了抑郁、疲劳和睡眠障碍表现为一组症状的观点。疲劳可能先于绝经前乳腺癌患者的抑郁症的非躯体症状，并代表一个潜在的干预目标。
Depression, fatigue, and sleep disturbances have been identified as a symptom cluster among breast cancer patients. However, few longitudinal studies have examined the temporal relations between these symptoms surrounding diagnosis and treatment. The current study investigated the co-occurrence of and interrelations between non-somatic depressive symptoms, fatigue, and sleep disturbances in breast cancer patients at three time points: prior to, after, and six to eight months following adjuvant chemotherapy treatment. Separate samples of premenopausal (N = 67) and postmenopausal (N = 67) breast cancer patients completed self-report measures of depression, fatigue, and sleep disturbances at all three time points. Path analysis was used to explore within- and cross-symptom paths across time. Depression, fatigue, and sleep disturbances were correlated within each time point. Continuity paths, whereby prior levels of symptom severity tended to predict subsequent severity of the same symptom at the subsequent time point, were significant in both samples, except for depression in the premenopausal sample. Instead, significant cross-symptom paths emerged whereby baseline fatigue predicted post-chemotherapy depression, and post-chemotherapy fatigue predicted depression at follow-up in the premenopausal patients. No significant cross-symptom paths emerged for the postmenopausal sample. Findings supported the notion that depression, fatigue, and sleep disturbances manifest as a symptom cluster. Fatigue may precede non-somatic symptoms of depression among premenopausal breast cancer patients and represents a potential intervention target.
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影响因子：
4.7
作者：
Carpenter, JS;Andrykowski, MA
通讯作者：
Andrykowski, MA
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
3.1
作者：
Roscoe, JA;Morrow, GR;Andrews, PLR
通讯作者：
Andrews, PLR
影响因子：
11.3
作者：
BUYSSE, DJ;REYNOLDS, CF;KUPFER, DJ
通讯作者：
KUPFER, DJ
影响因子：
--
作者：
Burgess, C;Cornelius, V;Ramirez, A
通讯作者：
Ramirez, A