Environmental control of collateral branching and target invasion of mitral cell axons during development.
Environmental control of collateral branching and target invasion of mitral cell axons during development.
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发育过程中二尖瓣细胞轴突的侧支分支和目标侵袭的环境控制。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Hajime Fujisawa
中科院分区：
文献类型：
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作者：
T. Hirata;Hajime Fujisawa
在发育过程中，作为嗅球的主要传出神经，二尖瓣细胞轴突在外侧嗅道（LOT）表现出漫长的等待期，然后发出侧枝并支配目标嗅皮层。为了研究目标入侵机制，我们对不同嗅皮质条的嗅球进行了一系列异时异位共培养。这些实验表明，二尖瓣细胞的侧枝发育是由环境因素引起的，而不是由内在机制引起的。侧枝诱导的提示与指导原代二尖瓣细胞轴突生长的提示明显不同。共培养实验还表明，目标嗅觉皮层经历了一个发育变化，成为二尖瓣细胞纤维的可接近性。然而，当遇到这两个位置时，初级二尖瓣细胞轴突仍然更倾向于LOT位置而不是梨状皮质。这些结果表明二尖瓣细胞的突起包括多个步骤，这些步骤受各种环境因素的控制。
During development, mitral cell axons, the major efferents of the olfactory bulb, exhibit a protracted waiting period in the lateral olfactory tract (LOT) before giving off collateral branches and innervating the target olfactory cortex. To investigate the target invasion mechanism, a series of heterochronic and heterotopic cocultures of olfactory bulbs with various olfactory cortical strips were conducted. These experiments indicated that development of collateral branches is triggered by environmental cues but not by intrinsic mechanisms in mitral cells. The collateral-inducing cues are apparently different from the cues directing outgrowth of primary mitral cell axons. Coculture experiments also indicated that the target olfactory cortex undergoes a developmental change to become accessible to mitral cell fibers. Primary mitral cell axons, however, still preferred the LOT position over such accessible piriform cortex when encountered both the locations. These results suggest that mitral cell projection comprises multiple steps which are controlled by various environmental cues.
通过抑制性膜结合分子控制地形视网膜轴突分支。
DOI：
10.1126/science.8047886
发表时间：
1994
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Roskies,AL;O'Leary,DD
通讯作者：
O'Leary,DD