The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.
The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.
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日本野生衍生的近交系小鼠品系，癌症研究中的MSM/Ms。
DOI：
10.3390/cancers13051026
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发表时间：
2021-03-01
期刊：
影响因子：
5.2
通讯作者：
Wakabayashi Y
中科院分区：
文献类型：
--
作者：
Okumura K;Saito M;Isogai E;Wakabayashi Y
由于对肿瘤易感性等位基因的人类研究需要来自癌症患者和匹配良好的对照的大量DNA样本，因此使用小鼠模型补充了对人类的研究和鉴定。然而，许多混杂因素与这种类型的研究有关，包括异质性，弱遗传相互作用和生活习惯。最近从野生小鼠中建立的近交系通常比标准近交系小鼠对致癌刺激和各种病原体更具抗性。日本野生近交系小鼠品系MSM/Ms在日本已被用于定位肿瘤抗性基因座以及其他数量性状基因座（QTL）。此外，已经开发了MSM/Ms的遗传工具。MSM/Ms基因组序列目前可用，这极大地促进了肿瘤抗性位点以及控制数量变异的基因的鉴定，并提供了对基因功能的更详细的理解。 MSM/Ms是源自日本野生小鼠Mus musculus molossinus的独特近交系小鼠品系，其与主要源自Mus musculus molossinus的标准近交系小鼠品系在遗传上相距约100万年。M.阿提库斯由于MSM/Ms的遗传分化，其在连锁研究中被广泛应用。构建了MSM/Ms基因组的细菌人工染色体（BAC）文库，序列分析表明，MSM/Ms基因组与常用的近交系小鼠C57 BL/6 J有约1%的核苷酸差异。因此，MSM/Ms小鼠被认为是有用的功能基因组研究。MSM/Ms小鼠表现出独特的表型特征，包括其较小的体型，对高脂饮食诱导的糖尿病的抵抗力，高运动活性，以及对年龄性听力损失，炎症和肿瘤发生的抵抗力，这些都不同于常见的近交系小鼠品系。此外，从MSM/Ms建立的ES（胚胎干）细胞系允许对MSM/Ms基因组进行遗传操作。因此，MSM/MS的基因组和表型分析揭示了以前没有从常见实验室菌株的研究中获得的基因功能的新见解。肿瘤发生相关的MSM/MS特异性遗传性状已在日本进行了深入研究。此外，辐射诱导的胸腺淋巴瘤和化学诱导的皮肤肿瘤已被广泛使用MSM/MS检查。
Since human studies on tumor susceptibility alleles require vast numbers of DNA samples from both cancer patients and well-matched controls, their investigation and identification in humans have been complemented using mouse models. However, a number of confounding factors are associated with this type of research, including heterogeneity, weak genetic interactions, and lifestyle habits. Inbred strains relatively recently established from wild mice are often more resistant to carcinogenic stimulation and various pathogens than standard inbred mouse strains. A Japanese wild-derived inbred mouse strain, MSM/Ms has been used to map tumor resistance loci as well as other Quantitative Trait Loci (QTL) in Japan. Furthermore, genetic tools have been developed with MSM/Ms. MSM/Ms genomic sequences are currently available, which have greatly promoted the identification of tumor resistance loci as well as genes controlling quantitative variations and provide a more detailed understanding of gene function. MSM/Ms is a unique inbred mouse strain derived from the Japanese wild mouse, Mus musculus molossinus, which has been approximately 1 million years genetically distant from standard inbred mouse strains mainly derived from M. m. domesticus. Due to its genetic divergence, MSM/Ms has been broadly used in linkage studies. A bacterial artificial chromosome (BAC) library was constructed for the MSM/Ms genome, and sequence analysis of the MSM/Ms genome showed approximately 1% of nucleotides differed from those in the commonly used inbred mouse strain, C57BL/6J. Therefore, MSM/Ms mice are thought to be useful for functional genome studies. MSM/Ms mice show unique characteristics of phenotypes, including its smaller body size, resistance to high-fat-diet-induced diabetes, high locomotive activity, and resistance to age-onset hearing loss, inflammation, and tumorigenesis, which are distinct from those of common inbred mouse strains. Furthermore, ES (Embryonic Stem) cell lines established from MSM/Ms allow the MSM/Ms genome to be genetically manipulated. Therefore, genomic and phenotypic analyses of MSM/Ms reveal novel insights into gene functions that were previously not obtained from research on common laboratory strains. Tumorigenesis-related MSM/Ms-specific genetic traits have been intensively investigated in Japan. Furthermore, radiation-induced thymic lymphomas and chemically-induced skin tumors have been extensively examined using MSM/Ms.
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影响因子：
2.5
作者：
Koide, T;Moriwaki, K;Shiroishi, T
通讯作者：
Shiroishi, T
DOI：
10.1016/j.bbrc.2007.02.003
发表时间：
2007-04-06
影响因子：
3.1
作者：
Kamimura, Kenya;Ohi, Hiroyuki;Kominami, Ryo
通讯作者：
Kominami, Ryo
影响因子：
2.4
作者：
Saito M;Okumura K;Miura I;Wakana S;Kominami R;Wakabayashi Y
通讯作者：
Wakabayashi Y
影响因子：
2.9
作者：
Fujiwara, Kyoko;Igarashi, Jun;Nagase, Hiroki
通讯作者：
Nagase, Hiroki
影响因子：
4.7
作者：
Kodama，Y;Yoshikai，Y;Kominami，R
通讯作者：
Kominami，R