A novel autophagy-related lncRNA prognostic risk model for breast cancer.
A novel autophagy-related lncRNA prognostic risk model for breast cancer.
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DOI：
10.1111/jcmm.15980
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发表时间：
2021-01
影响因子：
5.3
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Li X;Jin F;Li Y
众所周知，长非编码 RNA (lncRNA) 是乳腺癌发展的关键调节因子，并与控制自噬有关。 LncRNA 也逐渐成为乳腺癌患者有价值的预后因素。识别对乳腺癌具有预后价值的自噬相关 lncRNA 至关重要。在这项研究中，我们通过构建来自癌症基因组图谱（TCGA）的自噬相关 mRNA-lncRNA 的共表达网络，鉴定了乳腺癌中与自噬相关的 lncRNA。我们通过单变量和多变量Cox比例风险分析评估了这些自噬相关lncRNA的预后价值，最终获得了由11种自噬相关lncRNA（U62317.4、LINC01016、LINC02166、C6orf99、LINC00992、BAIAP2-DT、AC245297.3、 AC090912.1、Z68871.1、LINC00578 和 LINC01871）。根据 Kaplan-Meier 分析、单变量和多变量 Cox 回归分析以及时间依赖性受试者工作特征 (ROC) 曲线分析计算出的风险评分，进一步验证了该风险模型作为乳腺癌患者的一种新型独立预后因素。此外，基于风险模型，通过主成分分析（PCA）和基因集富集分析（GSEA）功能注释，低风险和高风险组表现出不同的自噬和致癌状态。综上所述，这些研究结果表明，11种自噬相关lncRNA的风险模型对乳腺癌具有显着的预后价值，并可能成为临床实践中自噬相关的治疗靶点。
Long non‐coding RNAs (lncRNAs) are well known as crucial regulators to breast cancer development and are implicated in controlling autophagy. LncRNAs are also emerging as valuable prognostic factors for breast cancer patients. It is critical to identify autophagy‐related lncRNAs with prognostic value in breast cancer. In this study, we identified autophagy‐related lncRNAs in breast cancer by constructing a co‐expression network of autophagy‐related mRNAs‐lncRNAs from The Cancer Genome Atlas (TCGA). We evaluated the prognostic value of these autophagy‐related lncRNAs by univariate and multivariate Cox proportional hazards analyses and eventually obtained a prognostic risk model consisting of 11 autophagy‐related lncRNAs (U62317.4, LINC01016, LINC02166, C6orf99, LINC00992, BAIAP2‐DT, AC245297.3, AC090912.1, Z68871.1, LINC00578 and LINC01871). The risk model was further validated as a novel independent prognostic factor for breast cancer patients based on the calculated risk score by Kaplan‐Meier analysis, univariate and multivariate Cox regression analyses and time‐dependent receiver operating characteristic (ROC) curve analysis. Moreover, based on the risk model, the low‐risk and high‐risk groups displayed different autophagy and oncogenic statues by principal component analysis (PCA) and Gene Set Enrichment Analysis (GSEA) functional annotation. Taken together, these findings suggested that the risk model of the 11 autophagy‐related lncRNAs has significant prognostic value for breast cancer and might be autophagy‐related therapeutic targets in clinical practice.
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DOI：
10.1146/annurev-cancerbio-041816-122338
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CANCER BIOLOGY, VOL 1
影响因子：
--
作者：
Santana-Codina, Naiara;Mancias, Joseph D.;Kimmelman, Alec C.
通讯作者：
Kimmelman, Alec C.
影响因子：
13.3
作者：
Chang, Chia-Hao;Bijian, Krikor;Alaoui-Jamali, Moulay A.
通讯作者：
Alaoui-Jamali, Moulay A.
影响因子：
21.3
作者：
Liu X;Xiao ZD;Han L;Zhang J;Lee SW;Wang W;Lee H;Zhuang L;Chen J;Lin HK;Wang J;Liang H;Gan B
通讯作者：
Gan B
DOI：
10.1093/annonc/mdt303
发表时间：
2013-09
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Goldhirsch A;Winer EP;Coates AS;Gelber RD;Piccart-Gebhart M;Thürlimann B;Senn HJ;Panel members
通讯作者：
Panel members
影响因子：
30.8
作者：
Kim J;Piao HL;Kim BJ;Yao F;Han Z;Wang Y;Xiao Z;Siverly AN;Lawhon SE;Ton BN;Lee H;Zhou Z;Gan B;Nakagawa S;Ellis MJ;Liang H;Hung MC;You MJ;Sun Y;Ma L
通讯作者：
Ma L