Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint.
Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint.
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从 microRNA 角度观察卡波西肉瘤相关疱疹病毒-宿主相互作用。
DOI：
10.3389/fmicb.2011.00271
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发表时间：
2011
影响因子：
5.2
通讯作者：
Lan K
中科院分区：
文献类型：
--
作者：
Liang D;Lin X;Lan K
卡波西肉瘤相关疱疹病毒（Kaposi's sarcoma-associated herpesvirus，KSHV），又称人类疱疹病毒8型（human herpesvirus 8），属于γ疱疹病毒属，是卡波西肉瘤、原发性渗出性淋巴瘤和某些类型的多中心Castleman病的病原体。在体内，KSHV主要感染B细胞和内皮细胞。KSHV与其宿主细胞之间的相互作用决定了病毒感染的结果和随后的病毒发病机制。microRNA（miRNAs）是一种小的非编码RNA，在微调细胞信号传导中非常重要。在感染期间，KSHV调节许多宿主miRNA（例如hsa-miR-132和hsa-miR-146 a）的表达谱和/或功能。同时，KSHV本身编码12个pre-miRNA，包括miR-K12-11，其是宿主miR-155的功能性直系同源物。在KSHV感染的细胞中发现了许多失调的细胞miRNA和病毒miRNA的细胞和病毒靶点，这表明miRNA可能在介导KSHV-宿主相互作用中起重要作用。在这篇综述中，我们总结了我们目前对KSHV如何调节宿主miRNAs的表达和/或功能的理解;我们详细回顾了miR-K12-11作为miR-155的直系同源物的功能;我们研究了病毒miRNAs在KSHV生命周期控制、免疫逃避和发病机制中的功能。
Kaposi’s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8, belongs to the gamma herpesviruses and is the etiological agent of Kaposi’s sarcoma, primary effusion lymphoma, and some types of multicentric Castleman’s disease. In vivo, KSHV mainly infects B cells and endothelial cells. The interactions between KSHV and its host cells determine the outcome of viral infection and subsequent viral pathogenesis. MicroRNAs (miRNAs) are small, non-coding RNAs that are important in fine-tuning cellular signaling. During infection, KSHV modulates the expression profiles and/or functions of a number of host miRNAs, for example hsa-miR-132 and hsa-miR-146a. Meanwhile, KSHV itself encodes 12 pre-miRNAs, including miR-K12-11, which is the functional ortholog of the host miR-155. A number of cellular and viral targets of deregulated cellular miRNAs and viral miRNAs are found in KSHV-infected cells, which suggests that miRNAs may be important in mediating KSHV–host interactions. In this review, we summarize our current understanding of how KSHV modulates the expression and/or functions of host miRNAs; we review in detail the functions of miR-K12-11 as the ortholog of miR-155; and we examine the functions of viral miRNAs in KSHV life cycle control, immune evasion, and pathogenesis.
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影响因子：
14.9
作者：
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通讯作者：
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影响因子：
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Flemington, Erik K.
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