Myocardial recovery in peripartum cardiomyopathy: prospective comparison with recent onset cardiomyopathy in men and nonperipartum women.
Myocardial recovery in peripartum cardiomyopathy: prospective comparison with recent onset cardiomyopathy in men and nonperipartum women.
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DOI：
10.1016/j.cardfail.2011.09.009
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发表时间：
2012-01
影响因子：
6
通讯作者：
McNamara, Dennis M.
中科院分区：
文献类型：
--
作者：
Cooper, Leslie T.;Mather, Paul J.;Alexis, Jeffrey D.;Pauly, Daniel F.;Torre-Amione, Guillermo;Wittstein, Ilan S.;Dec, G. William;Zucker, Mark;Narula, Jagat;Kip, Kevin;McNamara, Dennis M.
在男性和非围产期女性中，围产期心肌病 (PPCM) 的心肌恢复是否比近期发病的心肌病更常见，尚未进行前瞻性评估。这是通过对心肌炎和急性心肌病 2 (IMAC2) 干预登记中的结果进行分析来检验的。 IMAC 2 招募了 373 名近期发病的非缺血性扩张型心肌病受试者。 LVEF 在入组时和六个月内进行评估，并对受试者进行长达 4 年的随访。比较男性（第 1 组）、非围产期女性（第 2 组）和 PPCM 受试者（第 3 组）的心肌恢复情况。该队列包括第 1 组 230 名受试者、第 2 组 104 名受试者和第 3 组 39 名受试者。第 1、2 和 3 组基线时的平均 LVEF 分别为 0.23±0.08、0.24±0.08 和 0.27±0.07 (p=0.04)，六个月时为 0.39±0.12， 0.42±0.11和0.45±0.14（p=0.007）。第 3 组的受试者在 6 个月时达到 LVEF > 0.50 的可能性比第 1 组或第 2 组要大得多（分别为 19%、34% 和 48%，p=0.002）。前瞻性评估证实，患有 PPCM 的女性心肌恢复最快，男性最差，非围产期女性则中等。在现代治疗中，近一半患有 PPCM 的女性心脏功能在六个月内恢复正常。
Whether myocardial recovery occurs more frequently in peripartum cardiomyopathy (PPCM), than in recent onset cardiomyopathies in men and non-peripartum women has not been prospectively evaluated. This was examined through an analysis of outcomes in the Intervention in Myocarditis and Acute Cardiomyopathy 2 (IMAC2) registry. IMAC 2 enrolled 373 subjects with recent onset non-ischemic dilated cardiomyopathy. LVEF was assessed at entry and six months, and subjects followed for up to 4 years. Myocardial recovery was compared between men (group1), non-peripartum women (group 2) and subjects with PPCM (group 3). The cohort included 230 subjects in group 1, 104 in group 2, and 39 in group 3. The mean LVEF at baseline in groups 1, 2, and 3 was 0.23±0.08, 0.24±0.08, and 0.27±0.07 (p=0.04), and at six months was 0.39±0.12, 0.42±0.11, and 0.45±0.14 (p=0.007). Subjects in group 3 had a much greater likelihood of achieving an LVEF >0.50 at 6 months than groups 1 or 2 (19 %, 34%, and 48% respectively, p=0.002). Prospective evaluation confirms myocardial recovery is greatest in women with PPCM, poorest in men, and intermediate in non-peripartum women. On contemporary therapy, nearly half of women with PPCM normalize cardiac function by six months.
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影响因子：
120.7
作者：
Pearson, GD;Veille, JC;Baughman, KL
通讯作者：
Baughman, KL
影响因子：
18.2
作者：
Sliwa, Karen;Hilfiker-Kleiner, Denise;McMurray, John J. V.
通讯作者：
McMurray, John J. V.
影响因子：
37.8
作者：
Sliwa, K;Damasceno, A;Mayosi, BM
通讯作者：
Mayosi, BM
影响因子：
4.8
作者：
Felker, GM;Jaeger, CJ;Baughman, KL
通讯作者：
Baughman, KL
影响因子：
9.8
作者：
Fett, JD;Carraway, RD;Pierre, R
通讯作者：
Pierre, R