Polymer biophotonic lab-on-chip devices with integrated organic semiconductor lasers
Polymer biophotonic lab-on-chip devices with integrated organic semiconductor lasers
复制标题
具有集成有机半导体激光器的聚合物生物光子片上实验室器件
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
U. Lemmer
中科院分区：
文献类型：
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作者：
T. Mappes;C. Vannahme;S. Klinkhammer;T. Woggon;M. Schelb;S. Lenhert;J. Mohr;U. Lemmer
我们提出了单次使用的光流体芯片实验室设备（loc）。在我们的方法中，我们的目标是聚甲基丙烯酸甲酯（PMMA）系统集成(a)有机激光器，(b)光波导，(c)微流控通道，(d)表面功能化，(e)荧光激发在一个芯片上。我们正在利用大规模生产技术来展示这种方法的适用性，通过避免电气互连，而只使用光学和流体接口。通过我们的实验，我们可以通过分别结合光路的两个连续元素（a - e）来证明这种方法的可行性：有机半导体激光器通过在分布式反馈（DFB）光栅上蒸发光活性材料薄膜来集成。为此，光栅母版通过热压印复制到PMMA块材料中。通过改变真空沉积有机半导体活性材料的厚度或DFB光栅周期来调谐可见光区的激光波长。DFB激光器发射的光通过深紫外光刻技术耦合到聚合物条形光波导中。波导允许对微流体通道进行光学引导。通过Dip-Pen纳米光刻（DPN）在微流体通道中定制表面功能化，可以局部激发荧光标记物，从而检测生物医学或环境相关流体中的选定成分。
We present optofluidic lab-on-a-chip devices (LOCs) for single use as disposables. In our approach we are aiming for systems out of poly(methyl methacrylate) (PMMA) that integrate (a) organic lasers, (b) optical waveguides, (c) microfluidic channels, (d) surface functionalization, and (e) fluorescence excitation on one single chip. We are utilizing mass production techniques to show the applicability of this approach by avoiding electrical interconnects but using optical and fluidic interfaces only. With our experiments we can show the feasibility of this approach by respectively combining two consecutive elements (a - e) of the path of light: Organic semiconductor lasers are integrated by evaporating a thin film of photoactive material on top of a distributed feedback (DFB) grating. For this purpose, grating masters are replicated by hot embossing into PMMA bulk material. The lasing wavelength in the visible light regime is tuned by altering the thickness of the vacuum deposited organic semiconductor active material or the DFB grating period. Emitted light from the DFB laser is coupled into polymer strip optical waveguides realized by Deep UV lithography. The waveguides allow optical guidance to a microfluidic channel. Tailored surface functionalization in the microfluidic channel by Dip-Pen Nanolithography (DPN) enables the local excitation of fluorescent markers and thus a detection of selected components in biomedical or environmentally relevant fluids.
影响因子：
56.9
作者：
Burns, MA;Johnson, BN;Burke, DT
通讯作者：
Burke, DT