Emerging Concepts of Motor Reserve in Parkinson's Disease.
Emerging Concepts of Motor Reserve in Parkinson's Disease.
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DOI：
10.14802/jmd.20029
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发表时间：
2020-09
影响因子：
3.9
通讯作者：
Sohn YH
中科院分区：
文献类型：
--
作者：
Chung SJ;Lee JJ;Lee PH;Sohn YH
阿尔茨海默病（AD）中认知储备（CR）的概念解释了个体之间对AD相关病理易感性的差异。增强的CR可能导致较少的认知缺陷，尽管严重的病理病变。帕金森病（PD）也是一种常见的神经退行性疾病，主要表现为与纹状体多巴胺能耗竭相关的运动功能障碍。帕金森病的运动缺陷程度与多巴胺耗竭程度密切相关;然而，仍然存在显著的个体差异。因此，我们假设运动储备（MR）的存在下，PD解释了运动缺陷的个体差异，尽管纹状体多巴胺耗竭水平相似。自2015年以来，我们使用初始临床表现和多巴胺转运蛋白PET扫描的数据进行了一系列研究，研究了PD初治患者的MR。在这篇综述中，我们总结了这些已发表的研究结果。特别是，一些发病前的经验（即，身体活动和教育）和可改变的因素（即，体重指数和脑影像学研究中的白色高信号）可以调节个体耐受PD病理的能力，这可以在疾病进展过程中维持。
The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. Parkinson’s disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. The degree of motor deficits in PD is closely correlated to the degree of dopamine depletion; however, significant individual variations still exist. Therefore, we hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion. Since 2015, we have performed a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan. In this review, we summarized the results of these published studies. In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual’s capacity to tolerate PD pathology, which can be maintained throughout disease progression.
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