A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?
A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?
复制标题
DOI：
10.1016/j.tim.2017.10.004
复制
发表时间：
2018-03
影响因子：
15.9
通讯作者：
Vasilakis N
中科院分区：
文献类型：
--
作者：
Sariol CA;Nogueira ML;Vasilakis N
寨卡病毒（ZIKV）的兴起及其不寻常的临床表现为投机性辩论提供了基础。继发性登革病毒（DENV）感染的临床严重性与抗体依赖性增强（ADE）相关，并且最近提出先前暴露于DENV可能使ZIKV临床结果恶化。在这篇观点文章中，我们分析了不同黄病毒和ADE之间的关系。我们讨论了在非人灵长类动物和人类队列中获得的新证据，证明当ZIKV感染在预先存在的DENV免疫的情况下发生时，与ADE没有相关性。我们建议在复杂的免疫黄病毒相互作用的背景下重新定义ADE，以便在将体外或体内观察结果转化为临床环境时提供更客观的视角。寨卡病毒（ZIKV）在先前暴露于其他黄病毒的地区引起非典型临床表现。不同的登革热-ZIKV交叉反应抗体在体外中和或增强ZIKV，但登革热免疫血清中和ZIKV的百分比非常低。登革热和西尼罗免疫血清对ZIKV的抗体依赖性增强（ADE）已经在体外显示，并且在免疫抑制小鼠中由登革热和西尼罗免疫血清诱导。在非人灵长类动物中未检测到先前登革热免疫引起的ZIKV ADE。在先前暴露于登革热的人类队列中没有记录ZIKV的ADE。ADE需要在临床结局的背景下重新定义。在将结果转化为人类时，需要仔细权衡小动物的体外和实验结果。需要进行前瞻性流行病学和临床研究，以确保先前暴露于登革热或其他黄病毒不会增加ZIKV的发病机制。
The rise of Zika virus (ZIKV) and its unusual clinical manifestations provided ground for speculative debate. The clinical severity of secondary dengue virus (DENV) infections is associated with antibody-dependent enhancement (ADE), and it was recently suggested that previous exposure to DENV may worsen ZIKV clinical outcomes. In this Opinion article we analyze the relationship among different flaviviruses and ADE. We discuss new evidence obtained in non-human primates and human cohorts demonstrating that there is no correlation to ADE when ZIKV infection occurs in the presence of pre-existing DENV immunity. We propose a redefinition of ADE in the context of complex immunological flavivirus interactions to provide a more objective perspective when translating in vitro or in vivo observations into the clinical setting. Zika virus (ZIKV) caused atypical clinical manifestations in areas with previous exposure to other flaviruses. Different dengue–ZIKV cross-reacting antibodies neutralize or enhance ZIKV in vitro, but the percentage of dengue immune serum neutralizing ZIKV is very low. Antibody-dependent enhancement (ADE) of ZIKV by dengue and West Nile immune sera has been shown in vitro and induced in immunosuppressed mice by dengue and West Nile immune sera. No ADE of ZIKV by previous dengue immunity was detected in non-human primates. No ADE of ZIKV was documented in a human cohort previously exposed to dengue. ADE needs to be redefined in the context of clinical outcomes. In vitro and experimental results in small animals need to be carefully weighed when translating results to humans. Prospective epidemiological and clinical studies are needed to reassure that previous exposure to dengue or other flaviviruses does not increase the pathogenesis of ZIKV.
登录
查看更多内容
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
DOI：
10.1073/pnas.0703498104
发表时间：
2007-05-29
影响因子：
11.1
作者：
Goncalvez, Ana P.;Engle, Ronald E.;Lai, Ching-Juh
通讯作者：
Lai, Ching-Juh
DOI：
10.4269/ajtmh.1980.29.638
发表时间：
1980-01-01
影响因子：
3.3
作者：
HALSTEAD, SB;PORTERFIELD, JS;OROURKE, EJ
通讯作者：
OROURKE, EJ
影响因子：
82.9
作者：
Osuna CE;Lim SY;Deleage C;Griffin BD;Stein D;Schroeder LT;Omange RW;Best K;Luo M;Hraber PT;Andersen-Elyard H;Ojeda EF;Huang S;Vanlandingham DL;Higgs S;Perelson AS;Estes JD;Safronetz D;Lewis MG;Whitney JB
通讯作者：
Whitney JB
影响因子：
2.4
作者：
Füst, G
通讯作者：
Füst, G