Hemopoietic stem cell inhibitor (SCI/MIP-1 alpha) also inhibits clonogenic epidermal keratinocyte proliferation.
Hemopoietic stem cell inhibitor (SCI/MIP-1 alpha) also inhibits clonogenic epidermal keratinocyte proliferation.
复制标题
造血干细胞抑制剂 (SCI/MIP-1 α) 还可抑制克隆性表皮角质形成细胞增殖。
DOI：
10.1111/1523-1747.ep12363603
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
I. Pragnell
中科院分区：
文献类型：
--
作者：
E Kenneth Parkinson;G. J. Graham;Pierre Daubersies;Julie E Burns;C. Heufler;Mark Plumb;Gerold Schuler;I. Pragnell
The maintenance and regulation of continuously renewing tissues is ultimately controlled at the level of stem-cell proliferation. We have recently identified a reversible inhibitor of hemopoietic stem-cell proliferation (stem-cell inhibitor [SCI]), which is identical to the macrophage inflammatory protein, MIP-1 alpha, a 69-amino-acid heparin-binding cytokine. To test the cell/tissue specificity of the inhibition of proliferation by SCI/MIP-1 alpha, we have investigated its activity on epidermal keratinocytes, the principal cell type of another continuously renewing tissue. Here we show that SCI/MIP-1 alpha inhibits the proliferation of epidermal keratinocytes in vitro and that the MIP-1 alpha mRNA is present in epidermal Langerhans cells but not in keratinocytes. This suggests an important growth regulatory function for SCI/MIP-1 alpha in keratopoiesis, as well as hemopoiesis, and may also indicate a novel role for the epidermal Langerhans cell. As SCI/MIP-1 alpha can inhibit the proliferation of embryologically distinct precursor cells, this raises the possibility that it may also function in a number of other tissues.
人类原角质形成细胞中两种功能不同的生长停滞状态，可调节克隆形成潜力。
DOI：
10.1111/1523-1747.ep12285684
发表时间：
1986
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Pittelkow,MR;WilleJr,JJ;Scott,RE
通讯作者：
Scott,RE
淋巴毒素、肿瘤坏死因子和γ干扰素对正常人角质形成细胞具有细胞抑制作用。
DOI：
10.1111/1523-1747.ep12696816
发表时间：
1989
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Symington,FW
通讯作者：
Symington,FW