Citric Acid Promoting B Lymphocyte Differentiation and Anti-epithelial Cells Apoptosis Mediate the Protective Effects of Hermetia illucens Feed in ETEC Induced Piglets Diarrhea.
Citric Acid Promoting B Lymphocyte Differentiation and Anti-epithelial Cells Apoptosis Mediate the Protective Effects of Hermetia illucens Feed in ETEC Induced Piglets Diarrhea.
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柠檬酸促进B淋巴细胞分化和抗上皮细胞凋亡介导黑水虻饲料对ETEC所致仔猪腹泻的保护作用
DOI：
10.3389/fvets.2021.751861
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发表时间：
2021
影响因子：
3.2
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Liu M;Yuan B;Jin X;Zhu M;Xu H;Xie G;Wang Z;Zhang X;Xu Z;Li B;Huang Y;Lv Y;Wang W
Newborn piglets are prone to diarrhea after weaning as a result of changes in their environment and feed. Enterotoxigenic Escherichia coli (ETEC) K88 strain is a typical pathogen that causes diarrhea in such stage of piglets. Hermetia illucens larvae are widely used in livestock and poultry production because of their high nutritional value and immunoregulatory effects. This study aimed to evaluate the protective effects of H. illucens feed in protecting against ETEC induced diarrhea in piglets and to unravel the mechanisms of immune modulation and intestinal barrier maintenance. The results showed that after ETEC infection, citric acid in the serum of the groups fed on H. illucens larvae increased significantly, which stimulated macrophages to secrete cytokines that promote B lymphocyte differentiation, ultimately increasing the production of IgA and IgG in serum. Concomitantly, citric acid also had a positive effect on the intestinal barrier damaged due to ETEC infection by inhibiting the production of inflammatory cytokines, reducing the Bcl-2/Bax ratio, and promoting the expression of tight junction proteins. Correlation analysis showed that the increase of citric acid levels might be related to Massilia. Thus, citric acid derived from H. illucens larvae can improve the immune performance of weaned piglets and reduce ETEC-induced damage to the intestinal barrier in weaned piglets.
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DOI：
10.1292/jvms.17-0236
发表时间：
2018-05-18
期刊：
The Journal of veterinary medical science
影响因子：
--
作者：
Lee J;Kim YM;Park YK;Yang YC;Jung BG;Lee BJ
通讯作者：
Lee BJ
影响因子：
9.7
作者：
Kesselheim, Aaron S.;Outterson, Kevin
通讯作者：
Outterson, Kevin
影响因子：
7
作者：
Qiao, Jiayun;Sun, Zeyang;Li, Haihua
通讯作者：
Li, Haihua
影响因子：
7
作者：
Biasato, Ilaria;Renna, Manuela;Gasco, Laura
通讯作者：
Gasco, Laura
影响因子：
5.4
作者：
Attia Z;Rowe JC;Kim E;Varikuti S;Steiner HE;Zaghawa A;Hassan H;Cormet-Boyaka E;Satoskar AR;Boyaka PN
通讯作者：
Boyaka PN