The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications.
The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications.
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DOI：
10.3390/cancers13205206
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发表时间：
2021-10-17
期刊：
影响因子：
5.2
通讯作者：
Pyeon D
中科院分区：
文献类型：
--
作者：
Powell SF;Vu L;Spanos WC;Pyeon D
头颈癌(HNC)是第六大常见癌症，每年导致全球近50万人死亡。HNC的两种亚型与吸烟/饮酒和/或人类乳头瘤病毒(HPV)感染明显相关。虽然非病毒性HNC的发病率在下降，但HPV阳性的HNC的发病率在过去几十年里急剧增加。从大量研究中积累的证据表明，HPV阳性和HPV阴性的HNC在突变、基因表达调控、治疗反应和患者存活率方面存在分子和临床差异。在这里，我们讨论了HNC研究和临床方法的现状，并提出了有待回答的问题和未来的方向。头颈部鳞状细胞癌(HNSCC)是一种独特的恶性肿瘤，与两种不同的危险因素有关：暴露于典型致癌物和人类乳头瘤病毒(HPV)感染。HPV编码强大的癌蛋白E6和E7，它们绕过了许多重要的致癌过程，导致癌症的发展。相比之下，HPV阴性的HNSCC是通过不同致癌驱动基因的多个突变而发展起来的。虽然与HPV阳性和HPV阴性的HNSCC相关的危险因素是离散的，但即使在相同的解剖亚型中，HNSCC患者仍然表现出高度复杂的分子特征、免疫渗透和治疗反应。在这里，我们总结目前对HPV阳性和阴性HNSCC的生物学机制、治疗方法和临床结果的理解。
Head and neck cancer (HNC) is the sixth most common cancer, causing almost half a million deaths worldwide every year. The two subtypes of HNC are distinctly associated with smoking/drinking and/or human papillomavirus (HPV) infection. While the incidence of non-viral HNC is decreasing, HPV-positive HNC incidence has dramatically increased in the last few decades. Accumulating evidence from numerous studies shows molecular and clinical differences in mutations, gene expression regulation, treatment responses, and patient survival rates between HPV-positive and HPV-negative HNC. Here, we discuss the current status of HNC research and clinical approaches and suggest unanswered questions and future directions. Head and neck squamous cell carcinoma (HNSCC) is a unique malignancy associated with two distinct risk factors: exposure to typical carcinogens and infection of human papillomavirus (HPV). HPV encodes the potent oncoproteins E6 and E7, which bypass many important oncogenic processes and result in cancer development. In contrast, HPV-negative HNSCC is developed through multiple mutations in diverse oncogenic driver genes. While the risk factors associated with HPV-positive and HPV-negative HNSCCs are discrete, HNSCC patients still show highly complex molecular signatures, immune infiltrations, and treatment responses even within the same anatomical subtypes. Here, we summarize the current understanding of biological mechanisms, treatment approaches, and clinical outcomes in comparison between HPV-positive and -negative HNSCCs.
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DOI：
10.1158/1541-7786.mcr-20-0884
发表时间：
2021-08
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Aldersley J;Lorenz DR;Mouw KW;D'Andrea AD;Gabuzda D
通讯作者：
Gabuzda D
HPV相关头颈鳞癌的免疫网络分析及其对疾病预后的影响
影响因子：
3.6
作者：
Chen, Xiaohang;Yan, Bingqing;Zhang, Fengmin
通讯作者：
Zhang, Fengmin
影响因子：
64.5
作者：
Chung H;Pamp SJ;Hill JA;Surana NK;Edelman SM;Troy EB;Reading NC;Villablanca EJ;Wang S;Mora JR;Umesaki Y;Mathis D;Benoist C;Relman DA;Kasper DL
通讯作者：
Kasper DL
影响因子：
11.2
作者：
Albers, A;Abe, K;Ferris, RL
通讯作者：
Ferris, RL
DOI：
10.1186/s41199-020-00059-1
发表时间：
2020-12-22
期刊：
Cancers of the Head & Neck
影响因子：
--
作者：
Cmelak A;Dietrich MS;Li S;Ridner S;Forastiere A;Burtness BA;Cella D;Murphy BA
通讯作者：
Murphy BA