Dynamic changes in histone acetylation regulate origins of DNA replication.
Dynamic changes in histone acetylation regulate origins of DNA replication.
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DOI：
10.1038/nsmb.1780
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发表时间：
2010-04
影响因子：
16.8
通讯作者：
中科院分区：
文献类型：
--
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While histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains largely unknown. Here, we describe a very efficient, single-step method to specifically purify histones located around an origin of replication from S. cerevisiae. Using high-resolution mass spectrometry, we have obtained a comprehensive view of the histone modifications surrounding the origin of replication throughout the cell cycle. We have discovered that histone H3 and H4 acetylation is dynamically regulated around an origin of replication, at the level of multiply-acetylated histones. Furthermore, we find that this acetylation is required for efficient origin activation during S-phase.
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Garcia, Benjamin A.;Hake, Sandra B.;Hunt, Donald F.
通讯作者：
Hunt, Donald F.
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