Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases.
Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases.
复制标题
干扰素刺激基因在中枢神经系统（CNS）病毒感染和神经系统疾病中的表达及机制
DOI：
10.3389/fimmu.2022.1008072
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
干扰素（IFN）与细胞表面受体结合，通过细胞内信号级联激活干扰素刺激基因（ISG）的表达。ISG及其表达产物具有多种生物学功能，如抗病毒和免疫调节作用，并且是IFN功能的必需效应分子。ISG以细胞特异性和区域特异性方式限制病毒在中枢神经系统（CNS）中的侵袭和复制。除了参与对病毒感染的天然免疫外，研究表明ISG在CNS疾病如神经炎症和神经退行性疾病的发病机制中是必不可少的。本综述的目的是提出一个宏观的概述ISGs的特点，限制病毒的神经侵袭和表达的ISGs潜在的病毒感染的CNS细胞。此外，我们阐明了神经系统炎症，神经精神疾病如抑郁症以及神经退行性疾病，包括阿尔茨海默病（AD），帕金森病（PD）和肌萎缩侧索硬化症（ALS）中ISGs表达的特点。最后，本文综述了近年来研究较多的几种ISG（ISG15、IFIT2、IFITM3）在中枢神经系统的抗病毒感染作用及其在神经系统疾病中的研究进展。
Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression products have various biological functions, such as antiviral and immunomodulatory effects, and are essential effector molecules for IFN function. ISGs limit the invasion and replication of the virus in a cell-specific and region-specific manner in the central nervous system (CNS). In addition to participating in natural immunity against viral infections, studies have shown that ISGs are essential in the pathogenesis of CNS disorders such as neuroinflammation and neurodegenerative diseases. The aim of this review is to present a macroscopic overview of the characteristics of ISGs that restrict viral neural invasion and the expression of the ISGs underlying viral infection of CNS cells. Furthermore, we elucidate the characteristics of ISGs expression in neurological inflammation, neuropsychiatric disorders such as depression as well as neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Finally, we summarize several ISGs (ISG15, IFIT2, IFITM3) that have been studied more in recent years for their antiviral infection in the CNS and their research progress in neurological diseases.
影响因子：
4.7
作者：
Huber AK;Duncker PC;Irani DN
通讯作者：
Irani DN
影响因子：
6.2
作者：
Fields, Jerel;Dumaop, Wilmar;Adame, Anthony;Ellis, Ronald J.;Letendre, Scott;Grant, Igor;Masliah, Eliezer
通讯作者：
Masliah, Eliezer