Recent Advances in the Semisynthesis, Modifications and Biological Activities of Ocotillol-Type Triterpenoids.
Recent Advances in the Semisynthesis, Modifications and Biological Activities of Ocotillol-Type Triterpenoids.
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奥克替醇型三萜类化合物的半合成、修饰及生物活性研究进展
DOI：
10.3390/molecules25235562
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发表时间：
2020-11-27
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Cao Y;Wang K;Xu S;Kong L;Bi Y;Li X
人参是世界上消费最广泛的草药之一，在对抗疲劳和缓解压力方面起着重要作用。人参的主要活性物质是人参皂苷。茴香醇型三萜是一种从越南人参中提取的非常有效的人参皂苷，因其潜在的抗菌、抗癌和抗炎特性而受到关注。近年来，对茴香醇类化合物的半合成、改性及其生物活性进行了广泛的研究。本文综述了香豆醇类化合物的半合成、修饰及其药理活性。报道了这些化合物的构效关系研究。这一综述将为奥的罗类衍生物的药物开发提供有益的信息。
Ginseng is one of the most widely consumed herbs in the world and plays an important role in counteracting fatigue and alleviating stress. The main active substances of ginseng are its ginsenosides. Ocotillol-type triterpenoid is a remarkably effective ginsenoside from Vietnamese ginseng that has received attention because of its potential antibacterial, anticancer and anti-inflammatory properties, among others. The semisynthesis, modification and biological activities of ocotillol-type compounds have been extensively studied in recent years. The aim of this review is to summarize semisynthesis, modification and pharmacological activities of ocotillol-type compounds. The structure–activity relationship studies of these compounds were reported. This summary should prove useful information for drug exploration of ocotillol-type derivatives.
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影响因子：
3.9
作者：
通讯作者：
--
影响因子：
5.1
作者：
Le Tran, Q;Adnyana, IK;Kadota, S
通讯作者：
Kadota, S
DOI：
10.1016/j.jpba.2009.08.013
发表时间：
2010-01-05
影响因子：
3.4
作者：
Joo, Kyung-Mi;Lee, Ji-Hae;Lim, Kyung-Min
通讯作者：
Lim, Kyung-Min
影响因子：
9.7
作者：
Konoshima, T;Takasaki, M;Yamasaki, K
通讯作者：
Yamasaki, K
影响因子：
2.9
作者：
Hien Minh Nguyen;Huy Truong Nguyen;Morita, Hiroyuki
通讯作者：
Morita, Hiroyuki