Inflammation and mesenchymal stem cell aging.
Inflammation and mesenchymal stem cell aging.
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DOI：
10.1016/j.coi.2011.05.007
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发表时间：
2011-08
影响因子：
7
通讯作者：
Lepperdinger G
中科院分区：
文献类型：
--
作者：
Lepperdinger G
随着年龄的增长，MSC监管网络逐渐恶化。MSC和HSC共同在骨髓中共享干细胞生态位。MSC特异性地与免疫细胞相互作用并分泌免疫调节分子。MSC微环境的慢性炎症导致不良表现。衰老环境中的MSC扰乱组织稳态和免疫学。在成年人中，间充质基质细胞含有组织特异性多能干细胞MSC，其可以在整个身体中找到。随着年龄的增长，指导MSC生物学的调控网络的严格控制逐渐恶化。MSC微环境中的异常，如慢性炎症，最终导致不良表现，如骨骼和肌肉中脂肪沉积的积累，严重损伤后愈合受损和纤维化，或造血和自身免疫改变。MSC还可以特异性地与多种免疫细胞相互作用，并且在这样做时，它们分泌细胞保护和免疫调节分子，这些分子与细胞间接触一起介导免疫调节过程。本文综述了干细胞壁龛中发生的分子机制和细胞相互作用的现有知识，这些壁龛是MSC和造血干细胞和祖细胞之间共同共享的，以及间充质和各种造血后代特别是T淋巴细胞之间发生的细胞内相互依赖性，最终扰乱组织稳态和免疫在高龄。
► MSC regulatory networks gradually deteriorate with advancing age. ► MSC and HSC jointly share a stem cell niche in the bone marrow. ► MSC specifically interact with immune cells and secrete immunoregulatory molecules. ► Chronic inflammation of the MSC microenvironment leads to adverse manifestations. ► MSC in an aging environment perturb both tissue homeostasis and immunology. In adults, mesenchymal stromal cells contain tissue-specific multipotent stem cells, MSC, which can be found throughout the body. With advancing age, tight controls of regulatory networks, which guide MSC biology, gradually deteriorate. Aberrations within the MSC microenvironment such as chronic inflammation eventually lead to adverse manifestations, such as the accumulation of fat deposits in bone and muscles, impaired healing and fibrosis after severe injury, or altered hematopoiesis and autoimmunity. MSC can also specifically interact with a large variety of immune cells, and in doing so, they secrete cytoprotective and immunoregulatory molecules, which together with intercellular contacts mediate immune modulatory processes. This review comprehends the current knowledge regarding molecular mechanisms and cellular interactions that occur in stem cell niches, which are jointly shared between MSC and hematopoietic stem and progenitor cells, as well as those intracellular interdependences taking place between mesenchymal and a wide variety of hematopoietic progeny in particular T lymphocytes, which eventually perturb tissue homeostasis and immunology at advanced age.
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