Impaired contraction of blood clots precedes and predicts postoperative venous thromboembolism.
Impaired contraction of blood clots precedes and predicts postoperative venous thromboembolism.
复制标题
血块的收缩受损在前并预测术后静脉血栓栓塞。
DOI：
10.1038/s41598-020-75234-y
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发表时间：
2020-10-26
影响因子：
4.6
通讯作者：
Litvinov RI
中科院分区：
文献类型：
--
作者：
Evtugina NG;Peshkova AD;Pichugin AA;Weisel JW;Litvinov RI
深静脉血栓（DVT）是手术干预的常见但不可预测的并发症。为了揭示血凝块收缩（回缩）与术后静脉血栓形成发生率之间的关系，对 78 名接受手术的脑肿瘤患者进行了研究，其中 23 名（29%）被诊断为术后 DVT。手术前 1-3 天以及手术后第 1 天和第 5-7 天进行凝块收缩测定以及其他止血和血液学测试。术后第一天，与未发生 DVT 的患者相比，随后发生 DVT 的患者的血栓收缩明显受到抑制。重要的是，这种差异至少在 DVT 发生前 5 天观察到。术后第一天的收缩减弱在患有恶性脑肿瘤、动脉粥样硬化、高血压的 DVT 患者以及术前和术中接受类固醇的患者中更为明显。这些结果表明，术后血栓收缩受损与即将发生的 DVT 相关，表明它是一种促血栓形成的危险因素和促进机制。凝块收缩测定对于评估良性和恶性脑肿瘤患者术后血栓形成的威胁具有预测价值。
Deep vein thrombosis (DVT) is a common but unpredictable complication of surgical interventions. To reveal an association between the blood clot contraction (retraction) and the incidence of postoperative venous thrombosis, 78 patients with brain tumors that were operated on were studied, of which 23 (29%) were diagnosed with postoperative DVT. A clot contraction assay, along with other hemostatic and hematologic tests, was performed 1–3 days before the surgery and on the 1st day and 5–7th days after the surgery. On the 1st postoperative day, clot contraction was significantly suppressed in patients who subsequently developed DVT, compared to the patients without DVT. Importantly, this difference was observed at least 5 days before DVT had developed. The weakening of contraction on the 1st postoperative day was more pronounced in the DVT patients with malignant versus benign brain tumors, atherosclerosis, hypertension, as well as in patients receiving steroids before and during the operation. These results indicate that impaired clot contraction in the postoperative period is associated with imminent DVT, suggesting that it is a prothrombotic risk factor and promotional mechanism. The clot contraction assay has a predictive value in assessing the threat of postoperative thrombosis in patients with benign and malignant brain tumors.
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