Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis.
Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis.
复制标题
DOI：
10.3389/fphys.2018.01268
复制
发表时间：
2018
影响因子：
4
通讯作者：
Tyagi SC
中科院分区：
文献类型：
--
作者：
Homme RP;Singh M;Majumder A;George AK;Nair K;Sandhu HS;Tyagi N;Lominadze D;Tyagi SC
糖尿病患者除了葡萄糖代谢异常外，还患有许多生理异常。这些异常通常通过调节几个炎症相关基因、其各自的基因产物、同型半胱氨酸代谢和细胞焦亡而导致全身炎症。这种稳态破坏的本质是通过上调免疫反应、增强视网膜新生血管、上调表观遗传事件以及扰乱细胞氧化还原调节系统来重置糖尿病患者的整体生理机能。这种病理生理环境的改变可能导致糖尿病视网膜病变（DR）的发展，这是一种伴有微血管并发症的威胁视力的眼部疾病。 DR 是导致全世界工作年龄成年人不可逆失明的最常见原因，因为它会导致视网膜严重的结构和功能重塑，视力下降，从而降低生活质量。在这篇手稿中，我们试图总结最近的进展和新见解，以探索免疫系统各组成部分及其代谢协调之间相互交织的串扰的本质，以阐明 DR 的病理生理学。了解与 DR 相关的细胞和分子因素的多方面性质可以揭示有效诊断、治疗、预后、预防工具的新靶标，以及最终对抗易感受试者 DR 发生和进展的策略。
Diabetic patients suffer from a host of physiological abnormalities beyond just those of glucose metabolism. These abnormalities often lead to systemic inflammation via modulation of several inflammation-related genes, their respective gene products, homocysteine metabolism, and pyroptosis. The very nature of this homeostatic disruption re-sets the overall physiology of diabetics via upregulation of immune responses, enhanced retinal neovascularization, upregulation of epigenetic events, and disturbances in cells’ redox regulatory system. This altered pathophysiological milieu can lead to the development of diabetic retinopathy (DR), a debilitating vision-threatening eye condition with microvascular complications. DR is the most prevalent cause of irreversible blindness in the working-age adults throughout the world as it can lead to severe structural and functional remodeling of the retina, decreasing vision and thus diminishing the quality of life. In this manuscript, we attempt to summarize recent developments and new insights to explore the very nature of this intertwined crosstalk between components of the immune system and their metabolic orchestrations to elucidate the pathophysiology of DR. Understanding the multifaceted nature of the cellular and molecular factors that are involved in DR could reveal new targets for effective diagnostics, therapeutics, prognostics, preventive tools, and finally strategies to combat the development and progression of DR in susceptible subjects.
登录
查看更多内容
影响因子：
16.2
作者：
Barathi S;Angayarkanni N;Pasupathi A;Natarajan SK;Pukraj R;Dhupper M;Velpandian T;Muralidharan C;Sivashanmugham M
通讯作者：
Sivashanmugham M
影响因子：
--
作者：
Brooks, HL;Caballero, S;Grant, MB
通讯作者：
Grant, MB
影响因子：
34.3
作者：
Bourne, Rupert R. A.;Stevens, Gretchen A.;Taylor, Hugh R.
通讯作者：
Taylor, Hugh R.
DOI：
10.1083/jcb.148.1.203
发表时间：
2000-01-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Allport JR;Muller WA;Luscinskas FW
通讯作者：
Luscinskas FW
影响因子：
4.6
作者：
Ascaso FJ;Huerva V;Grzybowski A
通讯作者：
Grzybowski A