The prognostic significance of race in nasopharyngeal carcinoma by histological subtype.
The prognostic significance of race in nasopharyngeal carcinoma by histological subtype.
复制标题
鼻咽癌组织学分型中人种的预后意义。
DOI：
10.1002/hed.26639
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Puram SV
中科院分区：
文献类型：
--
作者：
Stepan KO;Mazul AL;Skillington SA;Paniello RC;Rich JT;Zevallos JP;Jackson RS;Pipkorn P;Massa S;Puram SV
鼻咽癌在美国是一种罕见的恶性肿瘤。种族和流行病学因素已被证明具有不同的预后意义；然而，先前的研究因缺乏全面的治疗、流行病学和共病数据而受到限制。2004-2016年全国鼻咽癌数据库研究。根据组织学分层的Kaplan-Meier曲线和Cox比例风险回归被用来计算总体生存的风险比，并调整协变量。10,147名患者符合标准。种族、保险、合并症、治疗、分期和年龄是独立的危险因素。未角化、未分化的鼻咽癌成活最好，角化最差。在角化性鼻咽癌中，亚洲人和拉美裔人显著提高了生存率(HR 0.58[95%CI 0.48-0.69]，HR 0.76[95%CI 0.61-0.96])。亚洲人和黑人在非角化性分化鼻咽癌中的生存率相似(HR 0.71[95%CI 0.56-0.91]，HR 0.72[95%CI 0.54-0.95])。种族是一个重要的预测因子，并且在鼻咽癌的组织学亚型中有所不同。
Nasopharyngeal carcinoma (NPC) is an uncommon malignancy in the United States. Race and epidemiological factors have been shown to have variable prognostic implications; however, previous studies are limited by the lack of comprehensive treatment, epidemiologic, and comorbidity data. National Cancer Database study for NPC from 2004–2016. Kaplan-Meier curves and Cox proportional hazards regressions stratified by histology were used to calculate hazard ratios for overall survival, adjusting for covariates. 10,147 patients met criteria. Race, insurance, comorbidities, treatment, stage, and age were independent risk factors. Non-keratinizing, undifferentiated NPC had the best survival, while keratinizing had the worst. Asians and Hispanics had significantly improved survival (HR 0.58 [95%CI 0.48 – 0.69], HR 0.76 [95%CI 0.61–0.96]) among keratinizing NPC. Asians and Blacks had similarly improved survival (HR 0.71 [95%CI 0.56–0.91], HR 0.72 [95%CI 0.54–0.95]) for non-keratinizing differentiated NPC. Race is a significant prognosticator and varies across histological subtypes of NPC.
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DOI：
10.1016/0360-3016(78)90138-4
发表时间：
1978-01-01
影响因子：
7
作者：
HOPPE, RT;WILLIAMS, J;BAGSHAW, MA
通讯作者：
BAGSHAW, MA
影响因子：
4.8
作者：
Lee, Hyun Woo;Hwang, Yoon Ho;Sheen, Seung Soo
通讯作者：
Sheen, Seung Soo
DOI：
10.1002/hed.10307
发表时间：
2003-10-01
影响因子：
2.9
作者：
Ma, BBT;Poon, TCW;Chan, ATC
通讯作者：
Chan, ATC
影响因子：
5.4
作者：
Almeida, Joanna;Molnar, Beth E.;Subramanian, S. V.
通讯作者：
Subramanian, S. V.
影响因子：
30.8
作者：
Kinker GS;Greenwald AC;Tal R;Orlova Z;Cuoco MS;McFarland JM;Warren A;Rodman C;Roth JA;Bender SA;Kumar B;Rocco JW;Fernandes PACM;Mader CC;Keren-Shaul H;Plotnikov A;Barr H;Tsherniak A;Rozenblatt-Rosen O;Krizhanovsky V;Puram SV;Regev A;Tirosh I
通讯作者：
Tirosh I