Retinoic acid alters EGF receptor expression during palatogenesis.
Retinoic acid alters EGF receptor expression during palatogenesis.
复制标题
视黄酸改变腭发育过程中 EGF 受体的表达。
作者：
B. Abbott;E. Adamson;R. Pratt
多种生长因子是正常胚胎发育所必需的，至少从妊娠第12天起，胚胎/胎鼠腭架发育中就存在EGF受体。腭架内侧上皮经历了一系列口腔和鼻上皮不发生的发育事件。在子宫和器官培养中，对照腭内侧上皮显示出EGF受体的发育下降，表现为抗体与EGF受体结合的减少和125I-EGF结合的减少；在邻近的口腔或鼻上皮细胞中未观察到的减少。在此期间，中间细胞停止DNA合成并经历程序性细胞死亡。暴露于全反式维甲酸的内侧上皮细胞继续表达EGF受体，结合EGF，增殖，不经历程序性细胞死亡，并表现出典型的鼻细胞形态。这些数据表明，维甲酸对EGF受体定位的干扰以及随后上皮细胞分化的改变在维甲酸介导的腭裂诱导中发挥了作用。
Various growth factors are necessary for normal embryonic development and EGF receptors are present in developing palatal shelves of embryonic/fetal mice at least from day 12 of gestation. The medial epithelium of the palatal shelf undergoes a series of developmental events which do not occur in the oral and nasal epithelia. In utero and in organ culture, the control palatal medial epithelium shows a developmental decline in EGF receptors, demonstrated both by a decrease in the binding of antibody to EGF receptors and a decrease in the binding of 125I-EGF; decreases which are not observed in cells of the adjacent oral or nasal epithelium. During this period, medial cells cease DNA synthesis and undergo programmed cell death. Medial epithelial cells exposed to all-trans-retinoic acid continue to express EGF receptors, bind EGF, proliferate, fail to undergo programmed cell death and exhibit a morphology typical of nasal cells. The data suggest that this disturbance by retinoic acid of EGF receptor localization and subsequent alterations in differentiation of the epithelial cells plays a role in the retinoic-acid-mediated induction of cleft palate.
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DOI：
--
发表时间：
1986-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
H. S. Earp§V;K. Austin;Joyce BlaisdellSg;R. A. Rubin;Karen G NelsonII;Lester W. LeelJ;Joe W. GrishamSJJ
通讯作者：
H. S. Earp§V;K. Austin;Joyce BlaisdellSg;R. A. Rubin;Karen G NelsonII;Lester W. LeelJ;Joe W. GrishamSJJ
小鼠表皮生长因子 (EGF) 受体单克隆和多克隆抗体的制备和特性：胚胎癌细胞中隐性 EGF 受体的证据。
DOI：
10.1242/dev.100.2.351
发表时间：
1987
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Weller,A;Meek,J;Adamson,ED
通讯作者：
Adamson,ED
DOI：
--
发表时间：
1976-10
期刊：
Journal of embryology and experimental morphology
影响因子：
--
作者：
R. Greene;R. Pratt
通讯作者：
R. Greene;R. Pratt
小鼠中 13-顺式视黄酸（异维A酸）的低致畸性对应于器官发生过程中的低胚胎浓度：与全反式异构体相比。
影响因子：
3.8
作者：
Kraft,JC;Kochhar,DM;Scott,WJ;Nau,H
通讯作者：
Nau,H