The validity of the dexamethasone suppression test as a marker for endogenous depression.
The validity of the dexamethasone suppression test as a marker for endogenous depression.
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地塞米松抑制试验作为内源性抑郁症标志物的有效性。
作者：
M. Zimmerman;W. Coryell;B. Pfohl
地塞米松抑制试验（DST）作为内源性抑郁症指标的有效性，最常通过检查其与内源性抑郁症操作标准的关系来检验。然而，这些标准本身并没有经过经验验证。我们在一系列假设和预测方面检查了DST，这些假设和预测与内源性抑郁症的理论结构一致。在连续入院的187例原发性单极抑郁症住院患者样本中，DST非抑制者年龄较大，有较少的病前人格障碍，更好的社会支持，较少的婚姻分居或离婚，入院前一年较少的非独立压力生活事件，在指数发作期间较少的非严重自杀企图，较少的功能失调态度。在他们的一级亲属中，接受酒精中毒治疗和反社会人格的比例较低。唯一明确的负面发现是DST结果与抑郁症家族史之间缺乏关联。我们的研究结果有力地支持了DST作为内源性抑郁标记的结构有效性。
The validity of the dexamethasone suppression test (DST) as an indicator of endogenous depression has been most frequently tested by examining its relationship to operational criteria of endogenous depression. However, these criteria sets themselves have not been empirically validated. We examined the DST in terms of a series of hypotheses and predictions that are consistent with the theoretical construct of endogenous depression. In a consecutively admitted sample of 187 primary unipolar depressed inpatients, the DST nonsuppressors were older, had less premobid personality disorder, better social support, less frequent marital separations or divorces, fewer nonindependent stressful life events during the year prior to admission, made fewer nonserious suicide attempts during the index episode, had fewer dysfunctional attitudes, and had a lower rate of treated alcoholism and antisocial personality in their first-degree relatives. The only clearly negative finding was the lack of association between DST results and family history of depression. Our results strongly support the construct validity of the DST as a marker of endogenous depression.
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地塞米松对精神病患者血浆催乳素和皮质醇水平的影响。
DOI：
10.1176/ajp.139.6.763
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Meltzer,HY;Fang,VS;Tricou,BJ;Robertson,A;Piyaka,SK
通讯作者：
Piyaka,SK
影响因子：
--
作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
重度抑郁症的下丘脑-垂体-肾上腺轴活动和三环反应。
影响因子：
--
作者：
Nelson,WH;OrrJr,WW;Stevenson,JM;Shane,SR
通讯作者：
Shane,SR
抑郁症的认知功能和地塞米松抑制试验。
DOI：
10.1176/ajp.141.1.116
发表时间：
1984
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Caine,ED;Yerevanian,BI;Bamford,KA
通讯作者：
Bamford,KA
DSM-III、RDC 和 ECT：抑郁亚型和即时反应。
DOI：
--
发表时间：
1984
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Rich,CL;Spiker,DG;Jewell,SW;Neil,JF
通讯作者：
Neil,JF