Prazosin during threat discrimination boosts memory of the safe stimulus.
Prazosin during threat discrimination boosts memory of the safe stimulus.
复制标题
DOI：
10.1101/lm.045898.117
复制
发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Schiller D
中科院分区：
文献类型：
--
作者：
Homan P;Lin Q;Murrough JW;Soleimani L;Bach DR;Clem RL;Schiller D
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that prazosin during threat acquisition may have influenced encoding or consolidation of safety processing in particular, subsequently leading to enhanced discrimination between the safe and threatening stimuli.
登录
查看更多内容
影响因子：
--
作者：
Gueorguieva, R;Krystal, JH
通讯作者：
Krystal, JH
影响因子：
2
作者：
Lazzaro, Stephanie C.;Hou, Mian;Cain, Christopher K.
通讯作者：
Cain, Christopher K.
影响因子：
2.6
作者：
Bach, Dominik R.
通讯作者：
Bach, Dominik R.
影响因子：
4.3
作者：
Barr, Dale J.;Levy, Roger;Scheepers, Christoph;Tily, Harry J.
通讯作者：
Tily, Harry J.
影响因子：
2.7
作者：
Do-Monte, Fabricio H. M.;Allensworth, Melody;Carobrez, Antonio P.
通讯作者：
Carobrez, Antonio P.