The Shape of Corneal Deformation Alters Air Puff-Induced Loading.
The Shape of Corneal Deformation Alters Air Puff-Induced Loading.
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DOI：
10.3389/fbioe.2022.848060
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发表时间：
2022
影响因子：
5.7
通讯作者：
Reilly, Matthew A.
中科院分区：
文献类型：
--
作者：
Yousefi, Atieh;Roberts, Cynthia J.;Reilly, Matthew A.
目的：通过考虑角膜变形来确定在充气试验中施加在眼睛上的载荷的动态修正。方法：角膜负荷随角膜表面形状(类别)的变化表现为在角膜表面切向流出的液体产生反向压力的凹陷阶段所产生的负荷的一个附加分量。计算了26例圆锥角膜(KCN)、102例正常人(NRL)和29例高眼压(OHT)患者的凹相位持续时间(TCD)、最大类间期(Class Max)和类-时间曲线下面积(CLASS INT)。图基的HSD测试被用来比较三组受试者。P值小于0.05被认为具有统计学意义。结果：在最大凹度时，班级负荷增加了34.6%±7.7%；这些差异在KCN组(P<；0.0001)更大，而在OHT组(P=0.0028)比NRL组更低。KCN组的T-CD和INT类显著长于NRL组和OHT组(P<；0.0001)。结论：负荷特性是评估角膜对空气诱导变形的生物力学反应的重要步骤。角膜表面形状的动态变化显著改变了角膜顶点所经历的负荷。这意味着特定于对象的加载动态，即使喷气本身是相同的。在手术或局部用药改变角膜特性后比较同一只眼睛时，这一点很重要。坚硬的角膜对负荷变化最不敏感，而柔韧的角膜表现出更高的敏感度。
Purpose: To determine the dynamic modification of the load exerted on the eye during air-puff testing by accounting for the deformation of the cornea. Methods: The effect of corneal load alteration with surface shape (CLASS) was characterized as an additional component of the load produced during the concave phase where the fluid outflow tangential to the corneal surface creates backward pressure. Concave phase duration (t CD ), maximum CLASS value (CLASS max ), and the area under CLASS-time curve (CLASS int ) are calculated for 26 keratoconic (KCN), 102 normal (NRL), and 29 ocular hypertensive (OHT) subjects. Tukey’s HSD tests were performed to compare the three subject groups. A p-value less than 0.05 was considered statistically significant. Results: Accounting for CLASS increased the load by 34.6% ± 7.7% at maximum concavity; these differences were greater in KCN subjects (p < 0.0001) and lower in OHT subjects (p = 0.0028) than in NRL subjects. t CD and CLASS int were significantly longer and larger, respectively, for KCN subjects than those in the NRL and OHT groups (p < 0.0001). Conclusion: Load characterization is an essential step in assessing the cornea’s biomechanical response to air-puff–induced deformation. The dynamic changes in the corneal surface shape significantly alter the load experienced by the corneal apex. This implies a subject-specific loading dynamic even if the air puff itself is identical. This is important when comparing the same eye after a surgical procedure or topical medication that alters corneal properties. Stiffer corneas are least sensitive to a change in load, while more compliant corneas show higher sensitivity.
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影响因子：
2.8
作者：
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通讯作者：
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DOI：
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