Application of Sustainable Natural Bioresources in Agriculture: Iodine-Mediated Oxidative Cyclization for Metal-Free One-Pot Synthesis of N-Phenylpyrazole Sarisan Analogues as Insecticidal Agents.
Application of Sustainable Natural Bioresources in Agriculture: Iodine-Mediated Oxidative Cyclization for Metal-Free One-Pot Synthesis of N-Phenylpyrazole Sarisan Analogues as Insecticidal Agents.
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可持续天然生物资源在农业中的应用：碘介导氧化环化一锅法无金属合成杀虫剂 N-苯基吡唑 Sarisan 类似物
DOI：
10.1021/acsomega.7b01106
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发表时间：
2017-09-30
期刊：
影响因子：
4.1
通讯作者：
Guo Y
中科院分区：
文献类型：
--
作者：
Qu L;Xu H;Wang X;Huang M;Deng L;Guo Y
In view of potential agricultural activity of sarisan (isolated from many plants or easily synthesized from sesamol, another biorenewable natural product) analogues, many research studies on the application of these biorenewable and abundant natural resources have been proceeded. A series of novel sarisan analogues containing N-phenylpyrazole were synthesized and evaluated for their insecticidal activity against a crop-threatening insect pest, Mythimna separata Walker. Meanwhile, an iodine-mediated oxidative intramolecular C–N bond formation methodology has been established for the one-pot synthesis of these N-phenylpyrazole-containing sarisan analogues. This practical one-pot methodology is metal-free and requires no separation of the less stable intermediate hydrazones. In addition, it was found that compounds 8l–r exhibited more promising insecticidal activity with the final mortality rates (FMRs) >62.1%, when compared with the positive control toosendanin. Especially, compound 8r with 2-fluoro-4-bromophenyl showed the most potent insecticidal activity, the FMR of which was 79.3%. On the basis of this, some interesting results of structure–activity relationships were also discussed.
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影响因子：
6.7
作者：
Dawood, Kamal M.;Eldebss, Taha M. A.;Metz, Peter
通讯作者：
Metz, Peter
影响因子：
3.5
作者：
Koca, Irfan;Ozgur, Aykut;Tutar, Yusuf
通讯作者：
Tutar, Yusuf
新型1,3,4-噻二唑吡唑肟衍生物的合成及生物活性
影响因子：
2.7
作者：
Dai, Hong;Li, Gang;He, Haibing
通讯作者：
He, Haibing
DOI：
10.1139/cjc-78-10-1345
发表时间：
2000-10-01
期刊：
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE
影响因子：
--
作者：
Majerus, SL;Alibhai, N;Durst, T
通讯作者：
Durst, T
影响因子：
3.8
作者：
MASUDA, T;INAZUMI, A;NAKATANI, N
通讯作者：
NAKATANI, N