The correlation between miRNA and lymph node metastasis in gastric cancer.
The correlation between miRNA and lymph node metastasis in gastric cancer.
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DOI：
10.1155/2015/543163
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发表时间：
2015
影响因子：
--
通讯作者：
Shyr YM
中科院分区：
文献类型：
--
作者：
Huang KH;Lan YT;Fang WL;Chen JH;Lo SS;Li AF;Chiou SH;Wu CW;Shyr YM
胃癌淋巴结转移（LNM）与癌症复发率高、预后差有关。因此，一个可靠的生物标志物预测LNM是重要的，将在临床实践中有价值。miRNA微阵列显示10种miRNA在LNM患者和非LNM患者中的表达有显著差异。共纳入46例胃癌患者，根据是否存在LNM分为两组（每组23例）。对这10种miRNAs进行RT-PCR检测并比较两组之间的差异。miR-1207- 5 p在无LNM的胃癌患者中与有LNM的患者相比显著上调。与miR-1207- 5 p下调或未改变的患者相比，miR-1207 - 5 p上调的患者的硬结间质反应较少，淋巴血管侵袭较少，病理T分类、N分类和TNM分期较早。多因素分析显示，间质反应类型、淋巴管浸润、病理T分类、TNM分期、miR-1207- 5 p表达是LNM的独立危险因素。miR-1207- 5 p可作为预测胃癌淋巴结转移的生物学指标。
Lymph node metastasis (LNM) in gastric cancer is associated with higher rate of cancer recurrence and poor prognosis. As a result, a reliable biomarker for the prediction of LNM is important and would be valuable in the clinical practice. MiRNA microarray revealed that ten miRNAs were expressed significantly different among patients with or without LNM. A total of 46 gastric cancer patients were enrolled and divided into two groups (23 in each group) according to the presence or absence of LNM. RT-PCR of these 10 miRNAs was investigated and compared between the two groups. MiR-1207-5p was significantly upregulated in gastric cancer patients without LNM compared with those with LNM. Patients with upregulated miR-1207-5p had less scirrhous stromal reaction, less lymphovascular invasion, and earlier pathological T category, N category, and TNM stage, compared with those with downregulated or unchanged miR-1207-5p. Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer.
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