Indinavir impairs endothelial function in healthy HIV-negative men.
Indinavir impairs endothelial function in healthy HIV-negative men.
复制标题
茚地那韦会损害健康的艾滋病毒阴性男性的内皮功能。
DOI：
10.1016/j.ahj.2005.06.005
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Steinberg,HelmutO
中科院分区：
文献类型：
--
作者：
Shankar,SudhaS;Dube,MichaelP;Gorski,JChristopher;Klaunig,JamesE;Steinberg,HelmutO
BACKGROUNDPotent antiretroviral treatment has drastically reduced mortality in HIV-infected patients but may accelerate atherosclerotic disease, which could be partially mediated via endothelial dysfunction.METHODSIn 8 HIV-negative healthy males, leg blood flow responses to intraartery infusions of methacholine chloride (Mch), sodium nitroprusside, and NG-mono-methyl-l-arginine (l-NMMA) were measured before and after 4 weeks of daily oral indinavir. In the same subjects, we also assessed the effect of indinavir on lipids, insulin sensitivity, markers of inflammation, as well as oxidative stress.RESULTSAfter 4 weeks of indinavir, the endothelium-dependent response to methacholine chloride was impaired (195% ± 38% vs 83% ± 13%, P < .05), the response to NG-mono-methyl-l-arginine (nitric oxide–dependent tone) was nearly abrogated (−30% ± 4% vs −1% ± 11%, P < .05), whereas the endothelium-independent response to sodium nitroprusside remained unchanged. Fasting insulin levels increased from 5.8 ± 1.2 to 7.0 ± 1.4 μU/mL (P < .05), and HOMA-IR scores increased from 1.3 ± 0.3 to 1.6 ± 0.3 U (P < .05). There were no changes in blood pressure, lipids, markers of inflammation, or oxidative stress.CONCLUSIONSFour weeks of the HIV-1 protease inhibitor indinavir, in the absence of HIV-1 infection, causes vascular dysfunction most likely at the level of endothelial nitric oxide production. The vascular dysfunction may be mediated partially by the concomitant induction of insulin resistance but other mechanisms cannot be ruled out.
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离子对高效液相色谱-紫外检测器同时定量测定人血浆中的HIV蛋白酶抑制剂安普那韦、茚地那韦、奈非那韦、利托那韦和沙奎那韦。
DOI：
10.1016/s0378-4347(98)00392-2
发表时间：
1998
期刊：
Journal of chromatography. B, Biomedical sciences and applications
影响因子：
--
作者：
R. V. van Heeswijk;R. Hoetelmans;R. Harms;P. Meenhorst;J. Mulder;J. Lange;J. Beijnen
通讯作者：
J. Beijnen
硝酸盐引起的内皮功能障碍的机制：实验和临床研究的见解
影响因子：
4.6
作者：
A. Warnholtz;N. Tsilimingas;M. Wendt;T. Münzel
通讯作者：
T. Münzel
影响因子：
3.8
作者：
Mary-Krause, M;Cotteb, L;Costagliola, D
通讯作者：
Costagliola, D
影响因子：
20.1
作者：
Timothy E. Peterson;Veronica Poppa;H. Ueba;A. Y. Wu;C. Yan;B. Berk
通讯作者：
Timothy E. Peterson;Veronica Poppa;H. Ueba;A. Y. Wu;C. Yan;B. Berk
影响因子：
--
作者：
BARON, AD;BRECHTEL, G;EDELMAN, SV
通讯作者：
EDELMAN, SV