Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats.
Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats.
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DOI：
10.3390/ijms11052056
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发表时间：
2010-05-05
影响因子：
5.6
通讯作者：
Gurtu S
中科院分区：
文献类型：
--
作者：
Erejuwa OO;Sulaiman SA;Wahab MS;Salam SK;Salleh MS;Gurtu S
高血糖对胰腺β-细胞有毒性作用。这项研究调查了一种假设，即常见的降糖药物格列本脲和二甲双胍与土郎蜜联合使用，可以为链脲佐菌素(STZ)诱导的糖尿病大鼠的胰腺提供额外的保护，防止氧化应激和损伤。雄性SD大鼠单次注射链脲佐菌素(60 mg/kg；ip)诱发糖尿病。糖尿病大鼠脂质过氧化(TBARS)水平显著升高，超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPX)活性上调，过氧化氢酶(CAT)活性显著降低。格列本脲和二甲双胍对糖尿病大鼠的TBARS和抗氧化酶无明显影响，但对GPX无明显影响。相反，格列本脲、二甲双胍和蜂蜜的组合显著上调CAT活性和下调GPX活性，而TBARS水平显著降低。这些结果表明，吐郎蜜增强了格列本脲和二甲双胍对糖尿病大鼠胰腺氧化应激和损伤的保护作用。
Hyperglycemia exerts toxic effects on the pancreatic β-cells. This study investigated the hypothesis that the common antidiabetic drugs glibenclamide and metformin, in combination with tualang honey, offer additional protection for the pancreas of streptozotocin (STZ)-induced diabetic rats against oxidative stress and damage. Diabetes was induced in male Sprague Dawley rats by a single dose of STZ (60 mg/kg; ip). Diabetic rats had significantly elevated levels of lipid peroxidation (TBARS), up-regulated activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) while catalase (CAT) activity was significantly reduced. Glibenclamide and metformin produced no significant effects on TBARS and antioxidant enzymes except GPx in diabetic rats. In contrast, the combination of glibenclamide, metformin and honey significantly up-regulated CAT activity and down-regulated GPx activity while TBARS levels were significantly reduced. These findings suggest that tualang honey potentiates the effect of glibenclamide and metformin to protect diabetic rat pancreas against oxidative stress and damage.
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