Oxygen microbubbles improve radiotherapy tumor control in a rat fibrosarcoma model - A preliminary study.
Oxygen microbubbles improve radiotherapy tumor control in a rat fibrosarcoma model - A preliminary study.
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DOI：
10.1371/journal.pone.0195667
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Dayton PA
中科院分区：
文献类型：
--
作者：
Fix SM;Papadopoulou V;Velds H;Kasoji SK;Rivera JN;Borden MA;Chang S;Dayton PA
癌症影响了39.6%的美国人在他们一生中的某个时候。实体瘤微环境的特征在于促进低氧（缺氧）区域的无序、渗漏的脉管系统。肿瘤缺氧是所有放疗（RT）、化疗和外科手术治疗结果不良的关键预测因素，也是转移潜力的标志。特别地，在低氧组织中实现与在常氧组织中相同的肿瘤控制概率所需的放射治疗剂量可以高达3倍。即使非常小的肿瘤（<2-3 mm 3）也包括10-30%的缺氧区域，其形式为在数秒至数天的过程中波动的慢性和/或短暂缺氧。我们研究了最近开发的脂质稳定的氧气微泡（OMBs），以提高RT的治疗比的潜力。OMBs，但不是氮气微泡（NMBs），显示出显着增加溶解氧含量时，加入到水中在体外，并增加在体内的大鼠纤维肉瘤模型中的肿瘤氧水平。在RT治疗之前立即进行OMB而不是NMB肿瘤内注射显著改善了肿瘤控制，并且如预期的那样，显示效应大小取决于RT治疗当天的初始肿瘤体积。
Cancer affects 39.6% of Americans at some point during their lifetime. Solid tumor microenvironments are characterized by a disorganized, leaky vasculature that promotes regions of low oxygenation (hypoxia). Tumor hypoxia is a key predictor of poor treatment outcome for all radiotherapy (RT), chemotherapy and surgery procedures, and is a hallmark of metastatic potential. In particular, the radiation therapy dose needed to achieve the same tumor control probability in hypoxic tissue as in normoxic tissue can be up to 3 times higher. Even very small tumors (<2–3 mm3) comprise 10–30% of hypoxic regions in the form of chronic and/or transient hypoxia fluctuating over the course of seconds to days. We investigate the potential of recently developed lipid-stabilized oxygen microbubbles (OMBs) to improve the therapeutic ratio of RT. OMBs, but not nitrogen microbubbles (NMBs), are shown to significantly increase dissolved oxygen content when added to water in vitro and increase tumor oxygen levels in vivo in a rat fibrosarcoma model. Tumor control is significantly improved with OMB but not NMB intra-tumoral injections immediately prior to RT treatment and effect size is shown to depend on initial tumor volume on RT treatment day, as expected.
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影响因子：
14
作者：
Feshitan JA;Legband ND;Borden MA;Terry BS
通讯作者：
Terry BS
影响因子：
2.6
作者：
BROWN, JM
通讯作者：
BROWN, JM
影响因子：
11.2
作者：
C치rdenas-Navia, LI;Yu, DH;Dewhirst, MW
通讯作者：
Dewhirst, MW
影响因子：
2.6
作者：
GRAY, LH;CONGER, AD;SCOTT, OCA
通讯作者：
SCOTT, OCA
影响因子：
5.7
作者：
HIRST, DG
通讯作者：
HIRST, DG